From a drought to HIV: An analysis of the effect of droughts on transactional sex and sexually transmitted infections in Malawi.

Each year there are over 300 natural disasters globally with millions of victims that cost economic losses near USD$100 billion. In the context of climate change, an emerging literature linking extreme weather events to HIV infections suggests that efforts to control the HIV epidemic could be under threat. We used Demographic and Health Survey (DHS) data collected during the 2015-2016 harsh drought that affected several areas of Malawi to provide new evidence on the effect of an unanticipated economic shock on sexual behaviours of young women and men.

Agriculture and forest land use change in the continental United States: Are there tipping points?

Land use in the United States (US) is driven by multiple forces operating at the global level, such as income and population growth, yield and productivity improvement, trade policy, climate change, and changing diets. Future land use has implications for biodiversity, run-off, carbon storage, ecosystem values, agriculture, and the broader economy. We investigate those forces and their implications from a multisector, multisystem dynamics (MSD) perspective focused on understanding dynamics and resilience in complex interdependent systems.

Is current irrigation sustainable in the United States? An integrated assessment of climate change impact on water resources and irrigated crop yields.

While climate change impacts on crop yields has been extensively studied, estimating the impact of water shortages on irrigated crop yields is challenging because the water resources management system is complex. To investigate this issue, we integrate a crop yield reduction module and a water resources model into the MIT Integrated Global System Modeling framework, an integrated assessment model linking a global economic model to an Earth system model. We assess the effects of climate and socioeconomic changes on water availability for irrigation in the U.

Estimating unbiased economies of scale of HIV prevention projects: a case study of Avahan.

Governments and donors are investing considerable resources on HIV prevention in order to scale up these services rapidly. Given the current economic climate, providers of HIV prevention services increasingly need to demonstrate that these investments offer good 'value for money'. One of the primary routes to achieve efficiency is to take advantage of economies of scale (a reduction in the average cost of a health service as provision scales-up), yet empirical evidence on economies of scale is scarce.

[18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging.

Purpose: The serotonin-1A (5-HT(1A)) receptor is implicated in the pathophysiology of major neuropsychiatric disorders. Thus, the functional imaging of 5-HT(1A) receptors by positron emission tomography (PET) may contribute to the understanding of its role in those pathologies and their therapeutics. These receptors exist in high- and low-affinity states and it is proposed that agonists bind preferentially to the high-affinity state of the receptor and therefore could provide a measure of the functional 5-HT(1A) receptors.