Biochemical and Structural Studies of the Carminomycin 4--Methyltransferase DnrK.

Structural and functional studies of the carminomycin 4--methyltransferase DnrK are described, with an emphasis on interrogating the acceptor substrate scope of DnrK. Specifically, the evaluation of 100 structurally and functionally diverse natural products and natural product mimetics revealed an array of pharmacophores as productive DnrK substrates. Representative newly identified DnrK substrates from this study included anthracyclines, angucyclines, anthraquinone-fused enediynes, flavonoids, pyranonaphthoquinones, and polyketides.

Pott's Puffy Tumor, a Forgotten Complication of Sinusitis: Report of Two Cases.

Pott's puffy tumor (PPT) is a life-threatening complication of infectious sinusitis/osteomyelitis of the frontal bone. It occurs due to infection or trauma and is often seen in late childhood and adolescence. If left untreated for a protracted period, intracranial complications such as epidural abscess, subdural empyema, meningitis, and a cerebral abscess may occur.

Enzyme-mediated bioorthogonal technologies: catalysts, chemoselective reactions and recent methyltransferase applications.

Transferases have emerged as among the best catalysts for enzyme-mediated bioorthogonal functional group installation to advance innovative in vitro, cell-based and in vivo chemical biology applications. This review introduces the key considerations for selecting enzyme catalysts and chemoselective reactions most amenable to bioorthogonal platform development and highlights relevant key technology development and applications for one ubiquitous transferase subclass - methyltransferases (MTs). Within this context, recent advances in MT-enabled bioorthogonal labeling/conjugation relevant to DNA, RNA, protein, and natural products (i.

Temporomandibular Joint Imaging.

The temporomandibular joint (TMJ) is an anatomically and biomechanically complex structure. Understanding how this structure grows and functions is essential to accurate radiographic evaluation. This article discusses the anatomy, function, and growth and development of the TMJ and how growth changes can affect the morphology of the craniofacial structures.

Squamous cell carcinoma arising within a maxillary odontogenic keratocyst: A rare occurrence.

Squamous cell carcinoma (SCC) arising within the lining of an odontogenic keratocyst (OKC) is a rare occurrence. Although potentially locally destructive, OKC is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. We present the clinical and radiographic features of a maxillary mass that demonstrated SCC arising from the lining of an OKC.

Analyzing Dental Implant Sites From Cone Beam Computed Tomography Scans on a Tablet Computer: A Comparative Study Between iPad and 3 Display Systems.

Purpose: The aim of this study was to compare a medical-grade PACS (picture archiving and communication system) monitor, a consumer-grade monitor, a laptop computer, and a tablet computer for linear measurements of height and width for specific implant sites in the posterior maxilla and mandible, along with visualization of the associated anatomical structures.

Material And Methods: Cone beam computed tomography (CBCT) scans were evaluated. The images were reviewed using PACS-LCD monitor, consumer-grade LCD monitor using CB-Works software, a 13″ MacBook Pro, and an iPad 4 using OsiriX DICOM reader software.

Prevalence of bony septa, antral pathology, and dimensions of the maxillary sinus from a sinus augmentation perspective: A retrospective cone-beam computed tomography study.

Purpose: Sinus elevation procedures have become a routine and reliable way to gain bone volume in the edentulous maxilla for dental implant placement. Presence of bony septations and pathology in the maxillary sinus often cause complications leading to graft or implant failure or both. The aim of this study was to retrospectively evaluate the prevalence of pathology, direction of the septa, and sinus width measured at 2 mm, 5 mm, and 10 mm from the sinus floor in maxillary sinuses using cone-beam computed tomography (CBCT).

Artifacts in Cone Beam Computed Tomography Image Volumes: An Illustrative Depiction.

Introduction: The evolution of cone beam computed tomography (CBCT) has brought about a paradigm shift in radiographic evaluation of the maxillofacial skeleton. Because of its low cost, high resolution, and relatively low-radiation dose, CBCT is fast becoming the 3-D imaging modality of choice in dentistry. The ubiquitous availability of this new imaging modality poses unique challenges in understanding this technology and recognizing the associated artifacts that present themselves in the acquired image volumes.

Arrested pneumatization of the sphenoid sinus mimicking intraosseous lesions of the skull base.

Arrested pneumatization of the sphenoid sinus is a developmental variant that is not always well recognized and is often confused with other pathologies associated with the skull base. This report describes the case of a patient referred for cone-beam computed tomography (CBCT) imaging for dental implant therapy. CBCT demonstrated a well-defined incidental lesion in the left sphenoid sinus with soft tissue-like density and sclerotic borders with internal curvilinear opacifications.

Using hand-held dental x-ray devices: ensuring safety for patients and operators.

Background: Since the introduction of hand-held x-ray units in dentistry, a few inexpensive devices have emerged that lack the necessary safety measures and failed to meet U.S. Food and Drug Administration (FDA) standards.