Publications by authors named "Elnaz Farahbakhshian"
Article Synopsis
- Researchers tested two growth factor cocktails (STF and STIF) to expand hematopoietic stem cells (HSCs) in vitro before transplantation, achieving significant increases in stem cell populations.
- Adding Angptl3 further boosted HSC expansion, indicating its potential direct and indirect roles in enhancing stem cell growth.
- The study found no signs of leukemia or toxicity in mice after transplanting the expanded HSCs, suggesting these methods could improve outcomes for umbilical cord blood and autologous stem cell therapies.
Pompe disease (acid alpha-glucosidase deficiency) is a lysosomal glycogen storage disorder characterized in its most severe early-onset form by rapidly progressive muscle weakness and mortality within the first year of life due to cardiac and respiratory failure. Enzyme replacement therapy prolongs the life of affected infants and supports the condition of older children and adults but entails lifelong treatment and can be counteracted by immune responses to the recombinant enzyme. We have explored the potential of lentiviral vector-mediated expression of human acid alpha-glucosidase in hematopoietic stem cells (HSCs) in a Pompe mouse model.
View Article and Find Full Text PDFBackground: The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, cellular ageing and senescence of cancer cells.
Results: We found that INK4b and INK4a, but not ARF, are upregulated following the differentiation of haematopoietic progenitor cells, in ageing fibroblasts and in senescing malignant rhabdoid tumour cells.