RACK1 promotes actin-mediated invasion, motility, and cell-to-cell spreading.

is an intracellular bacterium that hijacks the host actin cytoskeleton to invade and disseminate within the colonic epithelium. 's virulence factors induce actin polymerization, leading to bacterial uptake, actin tail formation, actin-mediated motility, and cell-to-cell spreading. Many host factors involved in the -prompted actin rearrangements remain elusive.