Publications by authors named "Elmir Mahammadov"
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how pluripotent stem cells are reprogrammed into totipotent-like 2-cell-like cells (2CLCs). We show that totipotent cells of the early mouse embryo have slow DNA replication fork speed and that 2CLCs recapitulate this feature, suggesting that fork speed underlies the transition to a totipotent-like state.
View Article and Find Full Text PDFCircadian rhythms are biological rhythms with a period close to 24 h. They become entrained to the Earth's solar day different periodic cues, so-called zeitgebers. The entrainment of circadian rhythms to a single zeitgeber was investigated in many mathematical clock models of different levels of complexity, ranging from the Poincaré oscillator and the Goodwin model to biologically more detailed models of multiple transcriptional translational feedback loops.
View Article and Find Full Text PDFArticle Synopsis
- Gastrulation is a crucial process in multicellular animals that establishes the body plan and cellular diversity, occurring in humans around the third week after fertilization.
- The study focuses on analyzing the single-cell transcriptional profiles of a human embryo during gastrulation, specifically between 16 and 19 days after fertilization.
- Findings reveal various cell types, including pluripotent epiblast and primordial germ cells, providing insights that enhance understanding of embryonic development and aid research on human cell differentiation.
Article Synopsis
- Cell competition is a process that helps get rid of weak or unhealthy cells in the body, especially during early development in mice.
- Researchers found that cells with problems in their mitochondria (which help produce energy) are the ones mostly eliminated during this process.
- They discovered that even small changes in mitochondrial DNA can cause these cells to be removed, making sure that the stronger, healthier cells stay to support proper development.