Correlation of the intracranial pressure to the central venous pressure in the late phase of acute liver failure in a porcine model.

Volume loading is a common method used to ensure adequate circulation. However, in the late phase of acute liver failure complications that often lead to death are cerebral swelling and brainstem edema, which are considered to result from increasing intracranial pressure (ICP). In former studies cerebral venous pressure (CVP) and ICP were reported to be independent entities.

The enterohepatic circulation of amanitin: kinetics and therapeutical implications.

Background: Amatoxin poisoning induces a delayed onset of acute liver failure which might be explained by the prolonged persistence of the toxin in the enterohepatic circulation. Aim of the study was to demonstrate amanitin kinetics in the enterohepatic circulation.

Methods: Four pigs underwent α-amanitin intoxication receiving 0.