Montmorillonite-Rifampicin Nanohybrid for pH-Responsive Release of the Tuberculostatic.

The present work describes the development of a hybrid and pH-responsive system for rifampicin using the clay mineral 'montmorillonite' as a nanocarrier. The influence of operational variables on the drug incorporation process was evaluated using 2 factorial designs. Under optimized conditions, the experiment allowed an incorporated drug dose equivalent to 98.

Photocatalytic degradation of Novacron blue and Novacron yellow textile dyes by the TiO/palygorskite nanocomposite.

The photocatalytic discoloration of industrial dyes, Novacron blue (NB) and Novacron yellow (NY), was investigated using composites based on TiO and natural palygorskite (Pal-Ti10 and Pal-Ti30). The method consisted of synthesizing the composites starting from a physical mixture of TiO and natural palygorskite in the presence of alcohol, for impregnation through calcination under conditions of temperature equal to 450 °C and atmospheric air. The characterization techniques used in this work were FTIR, XRD, XRF, SEM, particle size analysis and zeta potential.

pH-responsive release system of topiramate transported on silica nanoparticles by melting method.

Incorporating drugs into silica matrices by the melting method can be applied to obtain drug delivery systems because they are governed by electrostatic type interactions, hydrogen bonding and hydrophilic-hydrophobic interactions between the drug and the silica surface. the melting method is an environmentally correct tool since it is free of organic solvent, low cost and with easy execution for the incorporation of drugs in silicas. Drugs delivery systems are very important for improving the treatment of chronic diseases.

Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug.

Despite having good efficacy in the treatment and prevention of tuberculosis, the administration of rifampicin (RIF) can cause serious side effects, resulting from the prolonged use of this substance. Thus, it is necessary to seek new systems for administering tuberculostatic drugs, to avoid unwanted adverse effects, increase their bioavailability and, consequently, improve their therapeutic efficacy. The present work describes the achievement of a pH-responsive system for RIF, using palygorskite, a fibrous clay mineral, as a nanocarrier.

Experimental design for optimization of the photocatalytic degradation process of the remazol red dye by the TiO/expanded perlite composite.

In this study, the photocatalytic decolorization of remazol red dye (RR) was evaluated using TiO based composites supported on the expanded perlite (T-EP-10% and T-EP-30%). The characterization techniques used in this work were IR, XRD, XRF and particle size analysis. In order to optimize the RR discolouration process, a factorial planning was applied.