Publications by authors named "Elmali A"

Congenital disorders of glycosylation (CDG) comprise a class of inborn errors of metabolism resulting from pathogenic variants in genes coding for enzymes involved in the asparagine-linked glycosylation of proteins. Unexpectedly to date, no CDG has been described for , encoding the alpha-1,2-glucosyltransferase catalyzing the final step of lipid-linked oligosaccharide biosynthesis. Genome-wide association studies (GWAS) of human traits in the UK Biobank revealed significant SNP associations with short sleep duration, reduced napping frequency, later sleep timing and evening diurnal preference as well as cardiac traits at a genomic locus containing a pair of paralogous enzymes and .

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  • This study explored the use of diffusion-weighted MRI to evaluate prostate cancer patients with Gleason score 7 tumors before radiotherapy, focusing on the correlation between MRI results, cancer characteristics, and treatment outcomes.
  • It was found that tumors classified as GS 3+4 had higher ADC values compared to GS 4+3 tumors, indicating a difference in disease aggression, with lower ADC values linked to poorer survival rates.
  • The research concluded that ADC values could serve as an effective biomarker to distinguish between different types of GS 7 tumors, with lower values correlating with a higher risk of disease progression and worse long-term outcomes.
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  • The study evaluated the outcomes of younger (< 70 years) and older (≥ 70 years) prostate cancer patients after receiving definitive radiotherapy, focusing on disease-free survival and side effects.
  • Findings showed similar 7-year biochemical disease-free survival and prostate cancer-specific survival rates between the two age groups, despite older patients having additional risk factors and comorbidities.
  • The research concluded that definitive radiotherapy is a safe and effective treatment for localized prostate cancer regardless of age, as older patients experience comparable rates of survival and toxicity to younger ones.
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  • - Perylene monoimide diesters and phenyl-linked bichromophores exhibit strong fluorescence in dilute solutions while generating very few triplet states post-excitation, indicating efficient energy relaxation.
  • - The monomer in solution tends to form non-emissive face-to-face dimers, which upon illumination create a triplet pair with a yield of 13%, and this triplet has a short lifetime of about 80 ps before it decays.
  • - When the concentration increases, self-association happens, especially with the -bridged bichromophore, resulting in reduced triplet formation in solvents like tetrahydrofuran at room temperature.
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Purpose: To assess the early metabolic response of the primary tumor using Gallium-68 (Ga)-labeled-prostate-specific membrane antigen positron emission tomography (Ga-PSMA-PET/CT), as well as the relationship between PSMA change in the primary tumor and PSA response after definitive radiotherapy (RT), either alone or in combination with androgen deprivation therapy (ADT) in intermediate risk prostate cancer (IR-PCa) patients.

Methods: The clinical data of 71 IR-PCa patients treated with RT alone (36 patients, 50.7%) or RT and ADT (35 patients, 49.

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Purpose: This study sought to determine the predictive and prognostic value of clinicopathological parameters and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hemoglobin (Hgb) level in predicting recurrence patterns and locoregional relapse-free survival (LRFS) and distant metastasis-free survival (DMFS) in cervical cancer patients receiving definitive chemoradiotherapy (ChRT).

Methods: This study included 261 cervical cancer patients treated with ChRT. The primary endpoints were the predictors of local recurrence (LR) and distant metastasis (DM), whereas the secondary endpoints were LRFS and DMFS.

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Introduction: Sleep disturbances are being increasingly recognized in association with autoimmune encephalitis (AIE). We investigated the prevalence of sleep-related symptoms and polysomnographic features of patients with AIE and the long-term outcomes in these patients in a multi-center, prospective study from Turkey.

Methods: We prospectively evaluated patients with definite AIE in a common database including demographics, AIE-related and sleep-related symptomatology.

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  • The study examined the effectiveness of PSMA PET/CT imaging compared to traditional imaging methods in treatment outcomes for patients with node-positive prostate cancer who received androgen deprivation therapy (ADT) and external radiotherapy (RT).
  • Results showed that patients assessed with PSMA PET/CT had significantly higher 5-year prostate cancer-specific survival rates (95.1%) compared to those who underwent conventional imaging (76.9%).
  • Findings suggested that factors such as the duration of ADT and post-RT PSA levels were crucial in predicting both progression-free survival and survival specific to prostate cancer, indicating that PSMA PET/CT provides better prognostic information for patient outcomes.
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Background/aim: To compare implant sparing irradiation with conventional radiotherapy (RT) using helical (H) and TomoDirect (TD) techniques in breast cancer patients undergoing immediate breast reconstruction (IBR).

Patients And Methods: The dosimetric parameters of 40 patients with retropectoral implants receiving 50.4 Gy delivered in 28 fractions were analyzed.

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Purpose: To compare the biochemical failure (FFBF) and prostate cancer specific survival (PCSS) rates of patients with intermediate-risk prostate cancer (IR-PC) who were treated with 6 months of androgen deprivation therapy (ADT) with 78 Gy to the prostate, those treated with ADT and focal boost (FB) of 86 Gy to intraprostatic lesion (IPL) using the simultaneous-integrated boost (SIB) technique, and those treated with SIB alone.

Materials And Methods: A retrospective analysis of 320 IR-PC patients treated between January 2012 and April 2021 was performed. Patients were divided into three groups based on their treatment arm: 78 + ADT (109 patients, 34.

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  • The study focused on identifying the clinical characteristics and electrodiagnostic subtypes of Guillain-Barré Syndrome (GBS) in Istanbul over a three-year period.
  • Researchers conducted two electrodiagnostic examinations for 177 GBS patients and compared criteria for differentiating between demyelinating and axonal subtypes, finding varied diagnosis frequencies based on the criteria used.
  • Results indicated that patients with anti-ganglioside antibodies had distinct clinical features, including less sensory symptoms and a more severe disease profile; no significant increase in GBS cases was noted during the COVID-19 pandemic.
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  • Researchers added MnO nanoparticles to PVP polymer nanofibers to improve their ability to limit light, using different concentrations of the nanoparticles.
  • Scanning Electron Microscopy (SEM) confirmed that the MnO nanoparticles were well integrated into the nanofibers, and increasing their concentration changed the optical characteristics, such as widening the band gap energy.
  • The study found that while higher concentrations of MnO enhanced nonlinear absorption (NA) behavior, it eventually weakened at very high light intensities, indicating a complex interaction of absorption mechanisms that can be useful in optoelectronic applications.
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The effect of aluminum (Al) concentration on the surface plasmon resonance (SPR) band position of aluminum/polyvinylpyrrolidone (Al/PVP) composite nanofibers was investigated to strengthen nonlinear absorption (NLA) and widen its spectral range. With increasing Al content in PVP nanofibers, the SPR band was shifted towards excitation wavelength and an improved NLA response was achieved. The NLA response was examined both experimentally, by conducting -scan experiments, and theoretically, using two models.

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Herein, a spiro rhodamine (Rho)-thionated naphthalimide (NIS) electron donor-acceptor orthogonal dyad (Rho-NIS) was prepared to study the formation of a long-lived charge separation (CS) state the electron spin control approach. The transient absorption (TA) spectra of Rho-NIS indicated that the intersystem crossing (ISC) occurs within 7-42 ps to produce the NIS state the spin orbit coupling ISC (SOC-ISC). The energy order of CS (2.

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Purpose: Delineation is a critical and challenging step in radiotherapy planning. Differences in delineation among observers are common, despite the presence of contouring guidelines. This study aimed to identify the inter-observer variability in the target volume delineation of computed tomography (CT)-guided brachytherapy for cervical cancer.

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BODIPY dyes substituted by phenol or -COOMe units at the meso-position (C8) with and without a distyryl group including a methoxy moiety at the -C3 and -C5 positions of the BODIPY have been synthesized to analyze the photophysical properties. To clarify the ground-state interaction, absorption and emission features were investigated in the THF environment. Extending the π-conjugation with the methoxy moiety at -C3 and -C5 positions of BODIPY leads to a spectral shifting of the absorption maxima toward red by 120 nm.

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