Publications by authors named "Elly Pilavachi"
Article Synopsis
- - The INNOVATE study examines the effectiveness of multiparametric MRI (mpMRI) before biopsy and seeks to find new biomarkers for men suspected of having prostate cancer, assessing how well current markers like PSA and PSA density (PSAD) work in this context.
- - Among 340 men who underwent mpMRI, nearly 57% had a follow-up MRI-targeted biopsy, with almost half of those biopsies revealing clinically significant prostate cancer (csigPCa). The study highlights that a considerable percentage of men with lower mpMRI scores (Likert 3 and 4) might not need a biopsy while still having psAD levels considered low-risk.
- - The findings suggest that while PSA and PSAD are used for evaluating
Objective: To identify the whole-body MRI (WB-MRI) image type(s) with the highest value for assessment of multiple myeloma, in order to optimise acquisition protocols and read times.
Methods: Thirty patients with clinically-suspected MM underwent WB-MRI at 3 Tesla. Unenhanced Dixon images [fat-only (FO) and water-only (WO)], post contrast Dixon [fat-only plus contrast (FOC) and water-only plus contrast (WOC)] and diffusion weighted images (DWI) of the pelvis from all 30 patients were randomised and read by three experienced readers.
Highly active anti-retroviral therapy has proved successful in reducing morbidity and mortality associated with HIV infection though it has been linked to increased risk of cardiovascular disease. To date, the direct effects of the anti-retroviral drugs Efavirenz, Tenofovir and Emtricitabine on the vasculature relaxant response have not been elucidated, which impaired may predispose individuals to cardiovascular disease. Increased cellular oxidative stress and overactivation of the DNA repair enzyme poly (ADP-ribose) polymerase (PARP) have been identified as central mediators of vascular dysfunction.
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