Publications by authors named "Elliott S"

Anadromous salmonids migrate seaward to exploit feeding and growth opportunities in marine habitats, yet how smolt biological characteristics influence their marine migratory behavior remains poorly understood. This study used 9 years of trout (Salmo trutta) population monitoring data from 15,595 tagged age-0+ parr, 1033 smolts detected migrating downstream in spring, and 99 adults detected returning from their first marine migration to the River Frome (Dorset, UK) to investigate the influence of smolt biological characteristics on their migration timing and maiden marine sojourn duration. Age-specific differences in the influence of smolt length on migration timing were found, with longer 1-year-old smolts emigrating later than their shorter counterparts within the same age class, but the opposite association existed for 2-year-old smolts.

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Radical-radical reaction channels are important in the pyrolysis and oxidation chemistry of perfluoroalkyl substances (PFAS). In particular, unimolecular dissociation reactions within unbranched -perfluoroalkyl chains, and their corresponding reverse barrierless association reactions, are expected to be significant contributors to the gas-phase thermal decomposition of families of species such as perfluorinated carboxylic acids and perfluorinated sulfonic acids. Unfortunately, experimental data for these reactions are scarce and uncertain.

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  • The review covers the genetic and epigenetic factors related to food allergies, including their inheritance and the advantages and limitations of study methods.
  • Genome-wide association studies have identified 16 significant genetic variants linked to food allergies, often overlapping with other allergic conditions.
  • The article emphasizes the importance of integrating genetic and epigenetic data for understanding disease mechanisms and suggests future implications for predicting food allergy risks and responses to treatment.
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Legumes are a predominant source of isoflavones, termed phytoestrogens, that mimic 17β-estradiol (E2). Phytoalexins are inducible isoflavones produced in plants subjected to environmental stressors (e.g.

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Purpose: The purpose of this study was to create and validate an anterior urethral stricture disease (aUSD) staging system based on the previously validated Length (L), Urethral Segment (S), and Etiology (E, LSE) classification system.

Materials And Methods: The Trauma and Urologic Reconstruction Network of Surgeons (TURNS) prospective database was used to create and validate the staging system. A novel Urethroplasty Triad Score was created to aid in ranking the stagings into stricture severity based on (1) functional outcomes, (2) location of urethral meatus (eg, orthotopic, perineal), and (3) number of surgeries required for repair.

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The classical psychedelic drug (+)-lysergic acid diethylamide (LSD) continues to attract considerable multidisciplinary interest, and over the last eight decades, many derivatives and analogs of LSD have been synthesized. One site on the ergoline scaffold of LSD that has been frequently modified is the N-position, with the N-acylated LSD derivative 1-acetyl-LSD (1A-LSD, ALD-52) being one of the earliest examples. In more recent years, several other alkylcarbonyl- and cycloalkylcarbonyl-substituted LSD derivatives have been evaluated, including several distributed as research chemicals.

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  • Pompe disease results from a deficiency in acid alpha-glucosidase, leading to muscle weakness, respiratory issues, and cardiomyopathy in infants; the only current treatment is enzyme replacement therapy (ERT).
  • A new approach using a Centyrin protein-conjugated short interfering RNA (siRNA) targets the transferrin receptor (CD71) and the GYS1 enzyme to inhibit glycogen synthesis, potentially restoring glycogen balance instead of just degrading it.
  • In tests on a Pompe mouse model, this novel siRNA conjugate effectively reduced GYS1 levels and glycogen accumulation, improving exercise performance, indicating its promise as a therapy for late-onset Pompe disease or in combination with ERT for infants.
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Legumes are a rich source of polyphenolic compounds known for their ability to promote health. Under stress conditions, legumes have been shown to produce higher levels of secondary metabolites, as a defensive mechanism. Hence, the present study aimed to induce legume seeds (e.

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The "jumping deer sign" is an ultrasonographic pattern that aids in identifying normal liver anatomy and distinguishing it from pathology. It includes the portal vein (deer's head and body), the gallbladder or cystic duct (tail), and the inferior vena cava (obstacle). This sign helps differentiate portal veins from intrahepatic ducts, crucial for diagnosing conditions like portal hypertension.

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The oxo-acid:ferredoxin oxidoreductase (OFOR) superfamily of enzymes are responsible for the reversible interconversion of CO and oxo-acids, using CoA-derivatives as co-substrates, and requiring redox equivalents in the form of a soluble redox-carrier protein ferredoxin (Fd). Ultimately, these enzymes are responsible for the reduction of CO to form pyruvate (in the case of PFOR) and oxo-glutarate (in the case of OGOR), by the reductive carboxylation reaction of acetyl-CoA and succinyl-CoA, respectively. The nature and kind of Fd that is the best redox-carrier to support the reductive reaction has been poorly studied to date.

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LGBTQIA+ individuals experience higher rates of sexual violence victimization than their heterosexual, cisgender counterparts. Emerging research suggests unique barriers to disclosure and help-seeking in the aftermath of sexual assault, but relatively little work has examined LGBTQIA+ identity-related concerns discussed in a help-seeking context. This study examined anonymous, archival data, from a sample of 292 visitors to the National Sexual Assault Online Hotline.

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  • Immune literacy has gained importance due to emerging infectious diseases, highlighting the need for better immunology education and coordinated teaching efforts.
  • A task force of educators developed a framework detailing six core competencies and twenty illustrative skills necessary for undergraduate immunology education, based on research questions regarding competency importance and clarity.
  • The resulting ImmunoSkills Guide provides valuable resources for educators, administrators, and policymakers to enhance immunology education in response to society's growing demand for this knowledge.
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The goal of this market research study was to determine the usability of a single-dose prefilled injector (SelfJect™) for administration of Acthar Gel (manufactured by Mallinckrodt Pharmaceuticals, UK) in patients with inflammatory diseases by obtaining feedback from patient and practitioner user groups in the US. Patients and healthcare professionals (HCPs) representing relevant therapeutic areas were enrolled in the study between February and March 2021. SelfJect was mailed to patients and HCPs prior to 90-min virtual video-recorded focus group sessions and 60-min 1:1 virtual interviews, respectively.

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Objective: Lupus nephritis (LN) is a major cause of morbidity and mortality, affecting up to 60% of patients with systemic lupus erythematosus (SLE). The perspectives of patients with SLE have been explored; however, little is known of the lived experiences of patients with LN.

Methods: Patients aged ≥18 years with biopsy-proven pure or mixed International Society of Nephrology/Renal Pathology Society Class III, IV or V LN were purposefully recruited from a Canadian lupus cohort to participate in a photovoice (visual-narrative participatory research method) exercise.

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