Publications by authors named "Elliot J Teo"
The Development of Non-Invasive Optical Brain Pulse Monitoring: A Review.
Med Devices (Auckl)
December 2024
Early detection of neurological deterioration in serious acute brain injury is seen as an important goal to reduce death and disability, but monitoring for neurological deterioration remains challenging. Routine methods, such as neurological examination and brain imaging, often identify brain injuries only after they have progressed to an irreversible stage. Alternate approaches such as invasive brain monitoring, are complex, costly and carry inherent risks.
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- After a subarachnoid hemorrhage (SAH), the brain can react in confusing ways that might lead to lack of blood flow later on.
- A new device called the brain pulse monitor can help us check important brain health information like pressure and oxygen levels non-invasively (without surgery).
- In a patient with a serious SAH, the device showed changes in brain pressure and oxygen levels, suggesting it could help detect problems early and understand how the blood vessels behave after this kind of injury.
Article Synopsis
- - Researchers developed a non-invasive brain pulse monitor that uses red light to detect blood flow signals from the brain's surface, offering a safer and cheaper alternative to traditional invasive intracranial pressure (ICP) monitoring.
- - A study involving 12 critically ill patients showed that the brain pulse monitor's signals closely resembled those of invasive ICP measurements, with both methods indicating increased amplitude in response to higher ICP levels.
- - An automated algorithm confirmed a strong correlation (R=0.66, P < 0.001) between the brain pulse waveform patterns and ICP levels, suggesting that this new monitoring technique could effectively measure ICP without surgery.
Neuroinflammation is a hallmark of hypoxic-ischemic injury and can be characterized by the activation of glial cells and the expression of inflammatory cytokines and chemokines. Interleukin (IL)-1β and tumor necrosis factor (TNF)α are among the best-characterized early response cytokines and are often expressed concurrently. Several types of central nervous system cells secrete IL-1β and TNFα, including microglia, astrocytes, and neurons, and these cytokines convey potent pro-inflammatory actions.
View Article and Find Full Text PDFBackground: The objective of this study was to systematically review the literature to determine the effect of combined hypothermia (HTH) and mesenchymal stem cell (MSC) therapy (administered during or immediately before or after HTH) compared with HTH alone on brain injury and neurobehavioural outcomes in animal models of neonatal hypoxic-ischaemic encephalopathy.
Methods: Primary outcomes assessed were neuropathological measures and neurobehavioural measures of brain outcome. Secondary outcomes were brain protein proinflammatory cytokine status.