Publications by authors named "Elliot G Wallace"
Article Synopsis
- Leptin, an adipose-derived hormone, is essential for reproductive function, and its absence can lead to hypothalamic hypogonadism in both sexes.
- PACAP-expressing neurons are influenced by leptin and play a role in reproductive behavior, with their absence leading to metabolic and reproductive issues in mice, showing differences between males and females.
- Research on PACAP and leptin receptors indicates that while PACAP is crucial for timing female puberty, it doesn't impact male puberty or adult female fertility, nor does estrogen receptor influence body weight or puberty onset significantly.
Reproductive dysfunction in women has been linked to high caloric diet (HCD)-feeding and obesity. Central resistance to leptin and insulin have been shown to accompany diet-induced infertility in rodent studies, and we have previously shown that deleting suppressor of cytokine signaling 3, which is a negative regulator of leptin signaling, from all forebrain neurons partially protects mice from HCD-induced infertility. In this study, we were interested in exploring the role of protein tyrosine phosphatase 1B (PTP1B), which is a negative regulator of both leptin and insulin signaling, in the pathophysiology of HCD-induced obesity and infertility.
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