Understanding and Managing Isolated Systolic Hypertension in the Elderly.

In summary, ISHT in the elderly is a result of the interaction of increased systemic vascular resistance and of progressive arterial stiffening. The early return of reflected pulse wave may add to peak SBP in the ascending aorta and central arteries, thereby increasing LV systolic stress (afterload). Antihypertensive therapy has been shown to be effective in the prevention of strokes associated with ISHT.