Evidence-Based Human Homeopathy and Veterinary Homeopathy. Comment on Bergh et al. A Systematic Review of Complementary and Alternative Veterinary Medicine: "Miscellaneous Therapies". 2021, , 3356.

(1) Background: Classical (=individualized) homeopathic therapy is based on the individual and not on the indication. (2) Methods: The prerequisite for conducting methodologically high-quality studies on indvidualized homeopathy is that the principles of homeopathy are considered, since the selection of the simile (the individually appropriate homeopathic medicinal product) is decisive for the effectiveness of the homeopathic treatment, because only an application lege artis can be effective for the respective patient. Apart from this, criteria for evidence-based medicine must be considered for design, conduction, documentation, and rating of studies in homeopathy.

SCLpred-MEM: Subcellular localization prediction of membrane proteins by deep N-to-1 convolutional neural networks.

The knowledge of the subcellular location of a protein is a valuable source of information in genomics, drug design, and various other theoretical and analytical perspectives of bioinformatics. Due to the expensive and time-consuming nature of experimental methods of protein subcellular location determination, various computational methods have been developed for subcellular localization prediction. We introduce "SCLpred-MEM," an ab initio protein subcellular localization predictor, powered by an ensemble of Deep N-to-1 Convolutional Neural Networks (N1-NN) trained and tested on strict redundancy reduced datasets.

[Evidence-based homeopathy and veterinary homeopathy, and its potential to help overcome the anti-microbial resistance problem - an overview].

The basic principles of homeopathy, and its legal and scientific foundations, are discussed in an overview to address the positions of the World Health Organization (WHO) and the commission of the European Union (EU) on complementary medicine. According to the WHO, the antimicrobial resistance problem poses a global threat. The EU Commission's current One Health Action Plan requests research in complementary medicine, the WHO urges member states to include complementary medicine in their national health policies.

Leadership and effective succession planning in health-system pharmacy departments.

Leadership succession planning is crucial to the continuity of the comprehensive vision of the hospital pharmacy department. Leadership development is arguably the main component of training and preparing pharmacists to assume managerial positions. Succession planning begins with a review of the organizational chart in the context of the institution's strategic plan.

IOM Review of FDA--approved biologics labeled or studied for pediatric use.

Background: Studies have examined the extent to which public policies such as the Best Pharmaceuticals for Children Act have increased pediatric information in drug labeling. Little attention has focused on pediatric labeling of biologics. This analysis examines the extent to which biologics are labeled for pediatric use or have been studied in children.

Efficacy of metformin and topiramate in prevention and treatment of second-generation antipsychotic-induced weight gain.

Objective: To review the literature describing the efficacy of metformin and topiramate for the treatment of second-generation antipsychotic-induced weight gain.

Data Sources: Articles were identified by searching the MEDLINE database (from 1949 through January 2010) using the key words metformin, topiramate, antipsychotic, weight, weight gain, and obesity.

Study Selection And Data Extraction: All randomized, placebo-controlled trials of metformin and topiramate were selected for review.

Homeopathy as replacement to antibiotics in the case of Escherichia coli diarrhoea in neonatal piglets.

Background: The use of antibiotics in the livestock sector is increasing to such an extent that it threatens negative consequences for human health, animal health and the environment. Homeopathy might be an alternative to antibiotics. It has therefore been tested in a randomised placebo-controlled trial to prevent Escherichia coli diarrhoea in neonatal piglets.

Involvement of hyaluronan in epidermal Langerhans cell maturation and migration in vivo.

Background: Langerhans cells (LC) normally reside in the epidermis, where they constantly monitor the integrity of this microenvironment. Skin exposure to reactive haptens or other pro-inflammatory stimuli triggers LC migration to the draining lymph nodes, where they function as potent antigen presenting cells. At the same time, migratory LC exhibit features of mature dendritic cells.

Functional roles of hyaluronan in B16-F10 melanoma growth and experimental metastasis in mice.

Although hyaluronan (HA), a high molecular weight glycosaminoglycan, is generally believed to regulate tumor growth, invasion, and metastasis, functional roles of HA have only been speculated indirectly from the outcome of blocking HA receptors (e.g., CD44).