Although COVID-19 was experienced as a traumatic event with long-lasting effects, there is limited data on its traumatic impact in relation to factors that can promote or threaten young people's mental wellbeing. This study investigated the association between sensory-processing sensitivity (SPS), resilience, and life satisfaction with COVID-19 trauma-related stress and whether resilience mediates the relationship between SPS and COVID-19 traumatic stress in a young sample. A total of 441 individuals aged between 16 and 25 years ( = 19.
View Article and Find Full Text PDFBackground: Social and material deprivation accelerate the development of multimorbidity, yet the mechanisms which drive multimorbidity pathways and trajectories remain unclear. We aimed to examine the association between health inequality, risk factors and accumulation or resolution of LTCs, taking disease sequences into consideration.
Methods: We conducted a retrospective cohort of adults aged 18 years and over, registered between April 2005 and May 2020 in general practices in one inner London borough ( = 826,936).
Background: Defining multimorbidity has proved elusive in spite of attempts to standardise definitions. For national studies, a broad definition is required to capture national diversity. For locally based studies, the definition may need to reflect demographic and morbidity patterns.
View Article and Find Full Text PDFBackground: Within randomized clinical trials (RCTs), coiling of the ruptured aneurysm to prevent rebleeding results in better outcomes than clipping in patients with aneurysmal subarachnoid hemorrhage (aSAH).
Objective: To study the association of coiling and clipping with outcome after aSAH in daily clinical practice.
Methods: In this controlled, nonrandomized study, we compared outcomes after endovascular coiling and neurosurgical clipping of ruptured intracranial aneurysms in an administrative dataset of 7658 aSAH patients (22 tertiary care hospitals from Europe, USA, Australia; 2007-2013).