Publications by authors named "Ellie Sweatman"
Cancer Drug Resist
January 2023
Article Synopsis
- PARP inhibitors have transformed the treatment of tumors with defective DNA repair, but their effectiveness is often reduced due to drug resistance.
- Recent research from our group has identified the lysine methyltransferase SETD1A as a new factor that contributes to this resistance.
- We explore the role of epigenetic changes and H3K4 methylation in this process, discussing how this knowledge could enhance the use of PARP inhibitors in clinical settings and offer potential strategies to overcome resistance in cancers.
Article Synopsis
- The 53BP1-RIF1-shieldin pathway is crucial for maintaining genome stability by preventing the degradation of DNA ends at double-strand breaks (DSBs).
- RIF1 is recruited to DSBs through interaction with phospho-53BP1 and is influenced by the methylation of histone H3 at lysine 4, mediated by SETD1A-BOD1L.
- Impairing SETD1A or BOD1L disrupts RIF1's ability to localize to DSBs, leading to issues in DNA repair and potential therapeutic resistance in certain cancer cells, highlighting the pathway's clinical significance.
