Publications by authors named "Ellie McIntosh"
Article Synopsis
- Breast cancer stem cells (CSCs) may drive recurrence and metastasis, and their relationship with epithelial to mesenchymal transition (EMT) remains controversial due to varying findings based on cell lines studied.
- The study presents a novel model connecting a mixed epithelial/mesenchymal (EM) signature with stemness across various contexts, including different cell lines and mouse models, indicating that co-expression of E and M signatures correlates with poor patient outcomes.
- Key findings show that hybrid E/M cells exhibit enhanced stem-like traits and cooperation in forming mammospheres, suggesting that this mixed state significantly contributes to cancer aggressiveness and undermines traditional cell classification based on differentiation.
