Publications by authors named "Ellie M Randolph"
A Novel Method to Determine Patient Skin Type: The Skin Analyzer.
Plast Reconstr Surg Glob Open
October 2023
Article Synopsis
- Measuring skin color for medical research typically requires expensive in-person equipment, but the Skin Analyzer application provides a more accessible and efficient alternative using photographs.
- This desktop app converts digital images to L*a*b color space to calculate an individual typology angle, correlating with Fitzpatrick skin types, achieving an accuracy of 80%.
- The app demonstrates high interrater reliability with a Krippendorff alpha of 0.84, making it a reliable tool for objectively assessing skin types, particularly for retrospective studies where traditional methods are not feasible.
Fibronectin (FN), a critical component of the extracellular matrix, is assembled into fibrils through a cell-mediated process. Heparan sulfate (HS) binds to the III module of FN, and fibroblasts lacking this glycosaminoglycan exhibit reduced FN fibril assembly. To determine if HS depends on III to control FN assembly, we deleted both III alleles in NIH 3T3 cells using the CRISPR-Cas9 system.
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