Publications by authors named "Ellie M Mueller"
Article Synopsis
- Researchers studied chronic diarrhea in rhesus macaques, which is often linked to various gastrointestinal issues, and found that it occurs spontaneously in these primates.
- The study tracked stool consistency and assessed inflammation through various methods over 12 years, finding recurrent diarrhea and inflammation despite normal endoscopic results.
- By applying left vagal nerve stimulation for 9 weeks, the severity of diarrhea and inflammation significantly decreased, suggesting that this model can help in understanding diarrhea and its treatments in ways that human studies cannot.
Background: Vagus nerve stimulation (VNS) is a FDA approved therapy regularly used to treat a variety of neurological disorders that impact the central nervous system (CNS) including epilepsy and stroke. Putatively, the therapeutic efficacy of VNS results from its action on neuromodulatory centers via projections of the vagus nerve to the solitary tract nucleus. Currently, there is not an established large animal model that facilitates detailed mechanistic studies exploring how VNS impacts the function of the CNS, especially during complex behaviors requiring motor action and decision making.
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