Publications by authors named "Ellie Hyun-Jung Cho"
The Golgi apparatus is a pivotal secretory organelle in membrane trafficking, a hub responsible for posttranslational modifications, sorting, and trafficking of newly synthetized proteins received from the endoplasmic reticulum (ER). Different protein cargoes have been shown to travel through the Golgi stacks with different kinetics. Dysregulated transport and altered residency time of cargoes in the Golgi can impair their functionality.
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- Arl5b is a small G protein located on the trans-Golgi network (TGN) that plays a crucial role in regulating the transport of endosomes to the TGN.
- Researchers used various techniques to identify Arl5b's interactive partners and nearby proteins, discovering 22 Golgi proteins, primarily composed of TGN-localised small G proteins like Rabs, Arfs, and Arls.
- The study highlights the importance of Arl5b in the recruitment of scaffold/tethering factors such as ACBD3, indicating a complex network of small G proteins that organizes the TGN membrane.
The intracellular trafficking of β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) and APP regulates amyloid-β production. Our previous work demonstrated that newly synthesized BACE1 and APP are segregated into distinct trafficking pathways from the trans-Golgi network (TGN), and that alterations in their trafficking lead to an increase in Aβ production in non-neuronal and neuronal cells. However, it is not known whether BACE1 and APP are transported through the Golgi stacks together and sorted at the TGN or segregated prior to arrival at the TGN.
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