The association between eveningness and autistic traits: Mediating effects of depression and insomnia.

There is a lack of research on the relationships between autistic traits and morningness-eveningness. The current research explored associations between autistic traits (preferences for routine, difficulties with imagination, difficulties with social skills, fixations with numbers and patterns, and difficulties with attention switching) and morningness-eveningness, including the component of Morning Affect (alertness/energy upon awakening). The potential mediation effects of depression and insomnia were also tested.

A chromatogram-simplified Streptomyces albus host for heterologous production of natural products.

Cloning natural product biosynthetic gene clusters from cultured or uncultured sources and their subsequent expression by genetically tractable heterologous hosts is an essential strategy for the elucidation and characterisation of novel microbial natural products. The availability of suitable expression hosts is a critical aspect of this workflow. In this work, we mutagenised five endogenous biosynthetic gene clusters from Streptomyces albus S4, which reduced the complexity of chemical extracts generated from the strain and eliminated antifungal and antibacterial bioactivity.