Publications by authors named "Elli Gourna-Paleoudis"
Regulatory approval of immune checkpoint inhibitors (ICIs) was based on results of large, randomized clinical trials, resulting in limited outcomes data in patient cohorts typically underrepresented in such trials. The objective of this study was to evaluate the efficacy and safety of ICIs in these unique patient cohorts. This is a multicenter, retrospective analysis of real-world data at six academic and community clinics in the United States from 1 January 2011 to 1 April 2018.
View Article and Find Full Text PDFBackground: Diverse representation in clinical trials is an important goal in the testing of a medical, diagnostic, or therapeutic intervention. To date, the desired level of trial equity and inclusivity has been unevenly achieved.
Methods: Employing the US National Library of Medicine's Clinicaltrials.
In the U.S., approximately half of maids and housekeeping cleaners are Latino or Hispanic, while the vast majority are women (88.
View Article and Find Full Text PDFArticle Synopsis
- In the United States, a significant majority (88.3%) of maids and housekeeping cleaners are female, with around half being Latinas, who face underrepresentation in health research, specifically related to cleaning practices.
- This study aims to investigate the knowledge, attitudes, and behaviors of Latinas in the cleaning industry, along with their cleaning practices in both occupational and home settings.
- The mixed-method approach included focus groups and a survey, revealing that many Latinas received informal training at home, often cleaned in groups, and had inconsistent use of personal protective equipment like gloves and masks, highlighting their exposure risks.
Patients with serious COVID infections develop shock frequently. To characterize the hemodynamic profile of this cohort, 156 patients with COVID pneumonia and shock requiring vasopressors had interpretable echocardiography with measurement of ejection fraction (EF) by Simpson's rule and stroke volume (SV) by Doppler. RV systolic pressure (RVSP) was estimated from the tricuspid regurgitation peak velocity.
View Article and Find Full Text PDFThe first coronavirus disease 2019 (COVID-19) patient in the state of New Jersey (NJ) was admitted on March 2, 2020. With the number of hospitalized patients increasing exponentially in the following days and no established treatment approaches, research was to play a significant role in this fight. To facilitate review of all COVID-19 research proposals in a large health care network in NJ, we established the COVID-19 Research Review Committee (RRC) and implemented a peer-review process prior to the Institutional Review Board submission.
View Article and Find Full Text PDFBackground: Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function.
Methods And Findings: This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey.