CFTR Modulators Dampen -Induced Reactive Oxygen Species Production by Cystic Fibrosis Phagocytes.

Excessive inflammation by phagocytes during infection is thought to promote lung function decline in CF patients. CFTR modulators have been shown to reduce colonization , however, their antifungal and anti-inflammatory mechanisms are unclear. Other treatments including azithromycin and acebilustat may dampen -induced inflammation due to their immunomodulatory properties.