Modelling and Optimization of Fluid Dynamics, Microparticles and Cell Loading in Microfluidics.

Organ-on-a-chip technology allows for the examination of cell cultures within dynamic systems to better understand biological pathways. The three-dimensional (3D) microenvironment in which cells reside influences their behavior and maturation via mechanobiological cues. Computational fluid dynamics can be used to model the incorporation of biomaterials and 3D constructs as well as in the spreading of cells in microfluidic devices.

Embracing Mechanobiology in Next Generation Organ-On-A-Chip Models of Bone Metastasis.

Bone metastasis in breast cancer is associated with high mortality. Biomechanical cues presented by the extracellular matrix play a vital role in driving cancer metastasis. The lack of models that recapitulate the mechanical aspects of the microenvironment hinders the development of novel targeted therapies.