Histologic findings of bevacizumab-treated human conjunctiva in Stevens-Johnson syndrome.

Purpose: To present the histopathologic findings of the conjunctiva of a patient with Stevens-Johnson syndrome (SJS)-associated ocular surface neovascularization (OSN) after topical bevacizumab (TB) treatment.

Methods: A 40-year-old man with SJS and OSN received topical bevacizumab (25 mg/mL) for 12 months in 1 eye in addition to previously bilaterally administered tobramycin/dexamethasone eye drops. He subsequently underwent bilateral release of symblephara to relieve diplopia.

Limbal relaxing incisions and Graves ophthalmopathy with lower eyelid retraction.

Limbal relaxing incisions (LRI) were performed in a 35-year-old man with Graves ophthalmopathy and lower eyelid retraction. He underwent intraocular lens exchange in 1 eye and cataract surgery in the other. Despite the return of normal thyroid function, aggressive lubrication, and antiinflammatory medication, the LRIs failed to heal, leaving gaps in the limbal cornea.

Surgery for hypotony in patients with juvenile idiopathic arthritis-associated uveitis.

Purpose: To describe the clinical response to cyclitic membrane excision of eyes with juvenile idiopathic arthritis (JIA)-associated uveitis and hypotony.

Methods: The clinical records of patients with JIA-associated uveitis in a tertiary referral center were reviewed. Those patients with JIA-associated uveitis and hypotony who underwent cyclitic membrane excision were included in the study.

Obliterative microangiopathy presenting as chronic conjunctivitis in a patient with relapsing polychondritis.

Purpose: To report histopathologic findings and treatment of obliterative microangiopathy in a patient with chronic conjunctivitis due to relapsing polychondritis (RP).

Methods: This interventional case report describes a 50-year-old woman with relapsing polychondritis was referred to the Ocular Immunology and Uveitis Service for bilateral tearing due to refractory chronic conjunctivitis. Ocular examination revealed the presence of bilateral follicular conjunctivitis.

Outcomes of treatment with immunomodulatory therapy in patients with corticosteroid-resistant juvenile idiopathic arthritis-associated chronic iridocyclitis.

Purpose: To describe the clinical outcome of patients with juvenile idiopathic arthritis (IA)-associated chronic iridocyclitis unresponsive to conventional therapy, in whom inflammation was eventually controlled using immunomodulatory therapy (IMT), and to determine if patients treated early with IMT have better visual acuity outcomes than those treated with corticosteroid alone.

Methods: Patients with JIA-associated chronic iridocyclitis receiving immunomodulatory therapy at the Ocular Immunology and Uveitis Service of the Massachusetts Eye and Ear Infirmary between 1981 and 2001 were studied.

Inclusion Criteria: JIA with chronic corticosteroid-dependent uveitis; IMT for a minimum of one year; minimum follow-up of three years; inflammation eventually controlled for a minimum of six consecutive months by IMT.

Mycophenolate mofetil as an immunomodulatory agent in the treatment of chronic ocular inflammatory disorders.

Purpose: To evaluate the outcomes of patients with chronic ocular inflammatory disease treated with mycophenolate mofetil as an immunosuppressive and steroid-sparing agent.

Design: Retrospective noncomparative interventional case series.

Participants: All patients with ocular inflammatory disease treated with mycophenolate mofetil at a single institution between 1998 and 2001.

Chronic postoperative endophthalmitis due to pseudomonas oryzihabitans.

Purpose: To report a case of chronic postoperative endophthalmitis caused by the gram-negative bacterium Pseudomonas oryzihabitans.

Design: Interventional case report.

Methods: A 77-year-old man was referred to our service for nonpainful uveitis in the right eye accompanied by increased intraocular pressure of 2 years' duration with onset 4 months after uncomplicated extracapsular cataract extraction and posterior chamber intraocular lens implantation.