Publications by authors named "Ellen M Paatela"
The DUX4 transcription factor is briefly expressed in the early embryo and is epigenetically repressed in somatic tissues. Loss of epigenetic repression can result in the aberrant expression of DUX4 in skeletal muscle and can cause facioscapulohumeral dystrophy (FSHD). Multiple factors have been identified as necessary to maintain epigenetic silencing of in skeletal muscle, but whether specific sequences at the locus are sufficient for epigenetic silencing has been unknown.
View Article and Find Full Text PDFArticle Synopsis
- DUX4 is a special protein that helps control how cells grow and change, especially in early development and certain diseases like muscular dystrophy and cancer.
- When DUX4 is not working right, it can mess up how proteins are made in cells, affecting their functions.
- The study shows that while DUX4 makes some proteins more, it also stops the production of others that help muscle development and the immune system fight cancer.