Publications by authors named "Ellen Lester"
Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been implicated in the prevention of obesity, its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose tissue expression inversely associated with adiposity and positively associated with genes involved in mitochondrial metabolism and markers of metabolic health in 700 Finnish men and 100 strains of inbred mice from the UCLA Hybrid Mouse Diversity Panel. To determine the anti-obesity actions of ERα in fat, we selectively deleted from white and brown adipocytes in mice.
View Article and Find Full Text PDFNational Analysis of Risk Factors for Nasal Fractures and Associated Injuries in Trauma.
Craniomaxillofac Trauma Reconstr
September 2019
Nasal fractures account for up to 58% of facial fractures. However, the literature characterizing associated injuries and risk factors for nasal fractures is sparse and is mostly composed of single-center experiences. This study sought to provide a large descriptive analysis and identify associated injuries and risk factors for nasal fractures in trauma using a national database.
View Article and Find Full Text PDFArticle Synopsis
- Bile acids serve dual roles as detergents for lipid absorption and as signaling molecules that activate the farnesoid X receptor (FXR), which is important for regulating bile acid levels and has therapeutic potential for liver diseases.
- FXR activation leads to a decrease in bile acid synthesis by reducing the production of cholesterol 7α-hydroxylase (Cyp7a1) mRNA, and this regulation involves a posttranscriptional mechanism for degrading Cyp7a1 mRNA.
- The RNA-binding protein Zfp36l1 is identified as an FXR target that influences Cyp7a1 mRNA levels; mice without hepatic ZFP36L1 showed reduced obesity and fat