Impact of gonadotrophin stimulation for assisted reproductive technology on ovarian ageing and menopause.

This study investigated whether menopausal age is inversely related to the number of assisted reproduction cycles and/or ampoules of FSH used, as an indication of the possibility that gonadotrophin treatment accelerates follicular depletion. A questionnaire addressing reproductive health, history and treatment was mailed to women who had been treated for infertility at Bourn Hall Clinic, Cambridge, between 1981 and 1994. Additional data were extracted from clinical records.