Publications by authors named "Ellen Hukkelhoven"
Coordinate control of different classes of cyclins is fundamentally important for cell cycle regulation and tumor suppression, yet the underlying mechanisms are incompletely understood. Here we show that the PARK2 tumor suppressor mediates this coordination. The PARK2 E3 ubiquitin ligase coordinately controls the stability of both cyclin D and cyclin E.
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- Mutation of brat and mei-P26 hinders the differentiation of progenitor cells, leading to tumour-like characteristics.
- The NHL domain is crucial for the growth suppressive function of TRIM-NHL family members, while TRIM3 is identified as a true tumour suppressor that inhibits cell growth.
- The study finds that the RING domain of TRIM3 is essential for its ability to promote growth suppression by facilitating the ubiquitination of the protein p21.
Phosphorylation of Tyr-88/Tyr-89 in the 3(10) helix of p27 reduces its cyclin-dependent kinase (CDK) inhibitory activity. This modification does not affect the interaction of p27 with cyclin-CDK complexes but does interfere with van der Waals and hydrogen bond contacts between p27 and amino acids in the catalytic cleft of the CDK. Thus, it had been suggested that phosphorylation of this site could switch the tumor-suppressive CDK inhibitory activity to an oncogenic activity.
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