Publications by authors named "Ellen Elisa De Roeck"
Article Synopsis
- The study investigates how physiological differences between males and females may influence the development of Alzheimer's Disease (AD) through metabolic pathways.
- Researchers analyzed 540 plasma metabolites in 695 participants to see how sex impacts their association with AD markers, revealing distinct metabolite changes in females and males with AD.
- The findings highlight specific metabolites related to neurotransmission and inflammation that could lead to personalized treatment approaches for Alzheimer's based on sex differences.
Objectives: The objective of this systematic review was (1) to give an overview of the available short screening instruments for the early detection of Alzheimer's disease (AD) and (2) to review the psychometric properties of these instruments.
Methods: First, a systematic search of titles and abstracts of PubMed and Web of Science was conducted between February and July 2015 and updated in April 2016 and May 2018. Only papers written in English or Dutch were considered.
Objectives: Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological, social, and environmental frailty.
View Article and Find Full Text PDFWe investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline.
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