Publications by authors named "Elleke Tissink"
Psychiatric disorders are complex clinical conditions with large heterogeneity and overlap in symptoms, genetic liability and brain imaging abnormalities. Building on a dimensional conceptualization of mental health, previous studies have reported genetic overlap between psychiatric disorders and population-level mental health, and between psychiatric disorders and brain functional connectivity. Here, in 30,701 participants aged 45-82 from the UK Biobank we map the genetic associations between self-reported mental health and resting-state fMRI-based measures of brain network function.
View Article and Find Full Text PDFNeurodegenerative diseases are a group of disorders characterized by neuronal cell death causing a variety of physical and mental problems. While these disorders can be characterized by their phenotypic presentation within the nervous system, their aetiologies differ to varying degrees. The majority of previous genetic evidence for overlap between neurodegenerative diseases has been pairwise.
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- This study examines the heritability of functional connectivity within resting-state networks (RSNs) in the brain, which is crucial for cognitive functions. !* -
- Researchers conducted genome-wide association studies to explore the genetic links between structural (RSN-SC) and functional connectivity (RSN-FC), finding specific genes related to the visual network's structure. !* -
- The results indicate that genetic variations primarily affect functional connectivity, with limited overlap in structural aspects, enhancing our understanding of how genetics influences brain organization and its implications for brain disorders. !*
Article Synopsis
- Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental health disorders that share similar symptoms and genetic backgrounds, and may have overlapping effects on brain connectivity.
- The study analyzed data from nearly 20,000 healthy individuals to examine how genetic risks for SCZ and BD affect brain connectivity using advanced imaging techniques and genome-wide association studies.
- Results indicated significant links between specific brain regions and genetic risks for both disorders, identifying multiple genomic loci associated with brain circuits relevant to SCZ and BD, supporting the idea that these genetic factors influence brain structure even in healthy individuals.
Cerebellar volume is highly heritable and associated with neurodevelopmental and neurodegenerative disorders. Understanding the genetic architecture of cerebellar volume may improve our insight into these disorders. This study aims to investigate the convergence of cerebellar volume genetic associations in close detail.
View Article and Find Full Text PDFLasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, including DNA methylation (DNAm), are inconsistent. Studies in perinatal tissues indicate that variability of DNAm at birth is best explained by the joint effects of genotype and prenatal environment. Here, we extend these analyses to postnatal stressors.
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