Phase transitions in biology: from bird flocks to population dynamics.

Phase transitions are an important and extensively studied concept in physics. The insights derived from understanding phase transitions in physics have recently and successfully been applied to a number of different phenomena in biological systems. Here, we provide a brief review of phase transitions and their role in explaining biological processes ranging from collective behaviour in animal flocks to neuronal firing.

Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latency.

Objectives: Current antiretroviral therapy can suppress HIV replication, increase CD4 count and result in increased lifespan. However, it cannot eradicate the virus due to the presence of latent provirus in cellular reservoirs, such as resting CD4+ T cells. Using combination latency-reversing agents to shock the virus out of latency for elimination through immune clearance or viral cytopathic effect is one of the most promising strategies for HIV eradication.

The twin spot generator for differential Drosophila lineage analysis.

In Drosophila melanogaster, widely used mitotic recombination-based strategies generate mosaic flies with positive readout for only one daughter cell after division. To differentially label both daughter cells, we developed the twin spot generator (TSG) technique, which through mitotic recombination generates green and red twin spots that are detectable after the first cell division as single cells. We propose wide applications of TSG to lineage and genetic mosaic studies.

Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.

Cellular signaling networks have evolved to enable swift and accurate responses, even in the face of genetic or environmental perturbation. Thus, genetic screens may not identify all the genes that regulate different biological processes. Moreover, although classical screening approaches have succeeded in providing parts lists of the essential components of signaling networks, they typically do not provide much insight into the hierarchical and functional relations that exist among these components.