Alterations in miRNA Expression and Their Role in the Pathogenesis of Cervical Cancer.

Background: Cervical cancer has a high incidence and mortality rate, affecting more than half a million women in 2018. Its development is strongly related to high-risk HPV infection. After infection, several cellular molecules are affected, including microRNAs (miRNAs), which are the focus of our study.

Alteration in the Expression of Circular Rnas and its association with the Development and Progression of Osteosarcoma, an Integrative Review with High Sensitivity Research.

Background: Osteosarcoma is the most common primary malignant bone tumor, mainly affecting children, young adults, and the elderly. It is an aggressive cancer with a poor prognosis, exhibiting low survival rates even with standard treatment. Recently, circular RNA molecules capable of influencing gene expression through various functions, with their main role being acting as microRNA sponges and reducing their intracellular expression, have been identified.

The Role of Extracellular Traps in HIV Infection.

Human immunodeficiency virus (HIV) infection is still an important public health problem, which justifies the research of new therapies to combat it. Recent studies show that Extracellular Traps (ETs) are cellular mechanisms useful in the capture and destruction of some viruses, such as the HIV. Here, we show that neutrophils from peripheral blood, genital tissues, and placenta are activated when exposed to human immunodeficiency virus type 1 (HIV-1) and release Neutrophil Extracellular Traps (NETs).

Accuracy of wearable electronic device compared to manual and automatic methods of blood pressure determination.

Blood pressure (BP) is the main biomarker for monitoring patients, as its lack of control above values considered normal is a modifiable risk factor for target organ damage. The aim of this study is to evaluate the accuracy of the wearable electronic device photoplethysmography technology (PPG) Samsung Galaxy Watch 4 in determining BP in young patients compared to manual and automatic methods of BP determination. This is a quantitative and cross-sectional study, following validation protocols for wearable devices and BP measurement.

Spirometric values associated with clinical form and risk of death and stroke in chagasic patients.

The aim of the present study was to compare pulmonary function among patients with different clinical forms and scores for risk of death and stroke. Patients were recruited from the Chagas Disease Ambulatory Service at the University of Rio Grande do Norte State (Mossoró, Brazil). The evaluation of pulmonary function was performed through spirometry techniques using a digital spirometer, and information about the clinical forms (cardiac, cardiodigestive, digestive and undetermined) and scores for risk of death (Rassi's risk-of-death score) and stroke was subsequently collected.

Changes in renal function increase the need for advanced ventilatory support and increase the risk of mortality in critically ill patients with COVID-19.

In addition to respiratory failure, another important outcome presented by patients hospitalized with coronavirus disease 2019 (COVID-19) is renal failure, which is related to increased severity of infection and a greater risk of mortality. Severity is often represented by the need for respiratory and/or life support, which can range from oxygen therapy to invasive mechanical ventilation. This study aimed to determine the association between the degree of renal and inflammatory impairment in patients with the need for advanced respiratory support and mortality.

Resignation, violence and filing complaint: social representations of the male aggressor from the perspective of the female victim of aggression.

The scope of this study is to analyze the social representations of the male aggressor from the perspective of the female victim of aggression. It is a qualitative and representational study conducted, using free narrative as the data-gathering tool, with twenty women who were under the protection of the Reference Center in Natal in the State of Rio Grande do Norte. ALCESTE 2010 software was used to analyze the textual data.

Strength training improves body composition, muscle strength and increases CD4+ T lymphocyte levels in people living with HIV/AIDS.

The establishment of physical training programs for people living with HIV/AIDS (PLWHA) has several benefits. The study aimed to analyze the effect of resistance training using prediction of intensity by subjective perception of effort (SPE) on body composition, muscle strength, and TCD4 lymphocyte levels in PLWHA. This a randomized controlled trial study.

Entomological triatomine indicators in the State of Rio Grande do Norte, Brazil.

This study aimed to describe the main entomological triatomine-related indicators in the western mesoregion of Rio Grande do Norte. This is a descriptive cross-sectional retrospective study developed on a historical analysis of information on the triatomine capture carried out by the Chagas Disease Control Program, from 2008 to 2013. Five species were captured, of which the Triatoma brasiliensis and Triatoma pseudomaculata, by occupying the domestic and peridomestic environment, sequentially, and Panstrongylus lutzi by the highest rate of natural infection.

Manifestations and strategies of coping with Chagas Disease that interfere in the quality of life of the individual: a systematic review.

We aimed to identify the manifestations and coping strategies of Chagas disease that influence the quality of life of the affected subject. This is a literature systematic review carried out in PubMed, SciELO and Lilacs databases, through which sixpapers were retrieved, in addition to six publications identified with the verification of the bibliographic list and four papers through manual search, which were independently evaluated by two reviewers. The variables addressed were set in the thematic axes manifestations of Chagas disease that interfere in the quality of life of the individual and coping strategies that influence the quality of life of patients affected by Chagas disease, subdivided into three realms, namely, physical, psychological and social.

[Adherence to condom use: the real behavior in the Northeast of Brazil].

Objective: To investigate the socioeconomic, demographic and cultural elements that interfere in the adherence to the use of condoms in an open population.

Methodology: A cross-sectional study with a quantitative approach was conducted through an explanatory household survey, in the municipality of Caraúbas, West Potiguar mesoregion, with 3 482 individuals older than 18. A Likert questionnaire was administered by community health agents in a household setting.

Health profile of freedom-deprived men in the prison system.

Objective: To understand the needs and health profile of men incarcerated in the Pau dos Ferros Regional Criminal Complex (Rio Grande do Norte, Brazil).

Methodology: Quanti-qualitative research conducted with 30 men incarcerated in November 2012. Semi-structured interviews were the primary data collection method.