Publications by authors named "Elke Neven"
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.
Arterioscler Thromb Vasc Biol
September 2008
Article Synopsis
- Scientists studied how a special protein called VEGF-B affects the growth of blood vessels in heart problems using mice with and without VEGF-B.
- They found that mice without VEGF-B had trouble growing new blood vessels in the heart after a blockage, while mice with extra VEGF-B did better at growing new vessels.
- However, VEGF-B didn’t seem to help with blood vessel growth in other parts of the body like skin and lungs, suggesting it mainly helps the heart.
The importance of the lymphangiogenic factor VEGF-D and its receptor VEGFR-3 in early lymphatic development remains largely unresolved. We therefore investigated their role in Xenopus laevis tadpoles, a small animal model allowing chemicogenetic dissection of developmental lymphangiogenesis. Single morpholino antisense oligo knockdown of xVEGF-D did not affect lymphatic commitment, but transiently impaired lymphatic endothelial cell (LEC) migration.
View Article and Find Full Text PDFLymph vessels control fluid homeostasis, immunity and metastasis. Unraveling the molecular basis of lymphangiogenesis has been hampered by the lack of a small animal model that can be genetically manipulated. Here, we show that Xenopus tadpoles develop lymph vessels from lymphangioblasts or, through transdifferentiation, from venous endothelial cells.
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