Anterior scleral thickness in Marfan syndrome: A quantitative analysis.

Purpose: To investigate the anterior scleral thickness (AST) in patients with Marfan syndrome (MFS).

Methods: A prospective, cross-sectional study was conducted at the Department of Ophthalmology, Ghent University Hospital, Ghent, including patients with a genetically confirmed clinical diagnosis of MFS and age-, gender- and axial length-matched controls. Subjects with known corneal, conjunctival or scleral pathology and a history of ocular surgery, including pars plana vitrectomy, recent contact lens use or high-grade astigmatism were excluded.

Long-Term Visual Outcome of Patients with Blau Syndrome.

Purpose: To document the long-term visual outcomes in patients with Blau syndrome.

Methods: A retrospective institutional cohort study was conducted, and 13 patients with genetically confirmed Blau syndrome were included. Demographic and clinical data were collected from standardised medical charts.

Definitions for Keratoconus Progression and Their Impact on Clinical Practice.

Purpose: There is currently no consensus on which keratoconus need cross-linking nor on how to establish progression. This study assessed the performance of diverse progression criteria and compared them with our clinical knowledge of keratoconus evolution.

Methods: This was a retrospective, longitudinal, observational study.

Concurrent Ocular and Cerebral Toxoplasmosis in a Liver Transplant Patient Treated with Anti-CD40 Monoclonal Antibody.

, an obligate intracellular parasitic protozoon, usually causes a mild, acute infection followed by a latent asymptomatic phase with tissue cysts or a chronic form with recurrent retinochoroiditis. However, immunocompromised patients can cause disseminated disease due to the reactivation of the latent tissue cysts or due to a primary infection. Here, we present a rare case of bilateral ocular toxoplasmosis and concurrent subacute toxoplasma encephalitis in a 70-year-old patient on anti-CD40 treatment following his liver transplant.

ACUTE SYPHILITIC NECROTIZING RETINITIS ASSOCIATED WITH PLACOID CHORIORETINITIS IN AN IMMUNOCOMPETENT PATIENT.

Purpose: We report an atypical case of combined acute syphilitic necrotizing retinitis and a contiguous acute syphilitic posterior placoid chorioretinitis in an HIV-negative, immunocompetent patient.

Method: Observational case report.

Results: A 56-year-old man presented with a one-week history of pain and blurred vision in the left eye.

Investigating the Link Between Visual Quality and Vision-Related Quality of Life in Patients With Keratoconus.

Purpose: The purpose of the study was to investigate the optical and visual determinants of vision-related quality of life (VR-QoL) in patients with keratoconus.

Methods: A cross-sectional case-control study was conducted at the Department of Ophthalmology, Antwerp University Hospital, Belgium. Patients previously diagnosed with keratoconus and healthy emmetropic or ametropic volunteers were included.

Influence of Specialty Contact Lens Wear on Posterior Corneal Tomography in Keratoconus Subjects.

Objective: To evaluate the effect of specialty contact lens (CL) wear on posterior corneal tomography in keratoconus subjects.

Methods: Patients with keratoconus who were wearing specialty CL were included in this retrospective cohort study. Tomographic parameters were evaluated with Scheimpflug imaging (Pentacam HR) before lens fitting and immediately after removal of CLs worn habitually for a period of several months.

Ligneous conjunctivitis mimicking preseptal cellulitis in a 3-month-old infant.

Background: Ligneous conjunctivitis is a very rare form of pseudomembranous conjunctivitis with few published cases in literature. We aim to describe the ocular findings and treatment in an infant with ligneous conjunctivitis resembling preseptal cellulitis on presentation.

Materials And Methods: Case report of a 3-month-old girl who was referred to a tertiary centre for ophthalmic assessment due to progressive eyelid oedema with no response to initiated topical and systemic antibiotics.

Influence of Author's Gender on the Peer-Review Process in Vision Science.

Purpose: To investigate the gender gap in first/last authors in vision science and whether gender affects manuscript review times.

Design: Observational retrospective database study.

Methods: First/last author's gender and country were assigned to 30 438 PubMed records (data derived from Q1-Q2 Ophthalmology journals for 2016-2020).

Overprescribing of Topical Ocular Corticosteroids and Antibiotics in Out-of-Hours Primary Care in Belgium.

Prescribing patterns by primary care physicians concerning ophthalmic problems were studied using the iCAREdata, a database containing information from the out-of-hours care setting in the Flanders region of Belgium. A very high percentage of prescribed ophthalmic medication was topical antibiotics (89.4%) with tobramycin as the most prevalent substance and in clear conflict with the prevailing guidelines.

Scheimpflug-Based Analysis of the Reflectivity of the Cornea in Marfan Syndrome.

Purpose: We sought to investigate corneal reflectivity in Marfan syndrome (MFS) on the basis of Scheimpflug light intensity distribution.

Methods: In a retrospective case-control analysis, the left eyes of 40 MFS patients and 40 age- and refraction-matched healthy controls were investigated. Patients with MFS meeting the Ghent II diagnostic criteria and with genetic confirmation of disease were included.

Forecasting Progressive Trends in Keratoconus by Means of a Time Delay Neural Network.

Early and accurate detection of keratoconus progression is particularly important for the prudent, cost-effective use of corneal cross-linking and judicious timing of clinical follow-up visits. The aim of this study was to verify whether a progression could be predicted based on two prior tomography measurements and to verify the accuracy of the system when labelling the eye as stable or suspect progressive. Data from 743 patients measured by Pentacam (Oculus, Wetzlar, Germany) were available, and they were filtered and preprocessed to data quality needs.

Determining the Most Suitable Tomography-Based Parameters to Describe Progression in Keratoconus. The Retrospective Digital Computer Analysis of Keratoconus Evolution Project.

Objectives: To identify the most suitable parameters to describe keratoconus progression.

Methods: Longitudinal retrospective cohort study. Monotonicity and consistency of over 250 parameters extracted from the Pentacam tomographies (Oculus, Germany) of 743 patients was analyzed.

Expanding the clinical spectrum and management of Traboulsi syndrome: report on two siblings homozygous for a novel pathogenic variant in .

Background: Traboulsi syndrome is a very rare, syndromic form of ectopia lentis that is potentially sight-threatening at a young age. It is characterized by typical facial, skeletal and ocular signs.

Materials And Methods: Two siblings, born to consanguineous parents, with a clinical phenotype consistent with Traboulsi syndrome, underwent extensive ophthalmic imaging and exome-based genetic testing.

Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update.

Background: Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30% of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20% of cases in Western countries.

Methods: In this review, we provide a comprehensive overview of the pathophysiology of uveitis associated with SIRDs.

Clinical Outcome of Hybrid Contact Lenses in Keratoconus.

Objectives: To report the clinical outcome of hybrid contact lens fitting in keratoconus.

Methods: A retrospective chart review was performed of keratoconus patients who had been fitted with hybrid contact lenses in one or both eyes. Patients with a history of previous intraocular surgery (except for corneal crosslinking) and relevant concurrent ocular disease limiting visual outcome were excluded.

The corneoscleral shape in Marfan syndrome.

Purpose: To investigate the corneoscleral shape in Marfan syndrome (MFS) patients.

Methods: Thirty eyes of 15 participants with molecularly proven MFS were included in this prospective, cross-sectional study. Optical biometry, Scheimpflug imaging, and corneoscleral topography (Eye Surface Profiler) were performed in all patients.

Mini-Scleral Lenses Improve Vision-Related Quality of Life in Keratoconus.

Purpose: To evaluate the effects of mini-scleral lenses on visual acuity (VA) and visual functioning in patients with keratoconus.

Methods: This prospective, interventional study examined the effects of mini-scleral lenses on VA and visual functioning in patients with keratoconus. Patients younger than 18 years or with a history of refractive surgery or corneal graft surgery were excluded.

Scleral shape and its correlation with corneal parameters in keratoconus.

Purpose: To assess the correlation of the scleral shape and corneal tomographic parameters in keratoconus.

Methods: Twenty eyes of 15 keratoconus patients with no previous specialty lens wear or ocular surgery were included in this study. Corneal imaging was obtained with the Pentacam HR and three-dimensional (3D) corneoscleral maps were acquired using the Eye Surface Profiler, ESP.

Logistic index for keratoconus detection and severity scoring (Logik).

Purpose: To develop an objective severity scoring system for keratoconus for the use in clinical practice.

Methods: Corneal elevation and minimum thickness data of 812 subjects were retrospectively collected and divided into two groups: one control group with normal topography in both eyes (304 eyes), and one keratoconus group (508 eyes). Keratoconus cases ranged from suspect to moderate and had at least 1 examination in 1 of 2 recruiting centres.

Repeatability of the Pentacam HR in Various Grades of Keratoconus.

Purpose: To evaluate the repeatability of an extensive number of relevant indices with the Pentacam HR in keratoconus of varying severity and normal eyes.

Design: Reliability analysis.

Methods: This study was performed at Antwerp University Hospital, Belgium, and enrolled 20 healthy volunteers (20 eyes) and 69 patients (69 eyes) with keratoconus.