Publications by authors named "Elke Govaerts"
Article Synopsis
- A multicenter randomized controlled trial evaluated the efficacy and safety of the C5 inhibitor zilucoplan in hospitalized COVID-19 patients with systemic inflammation and hypoxemia.
- Out of 81 participants, those receiving zilucoplan showed greater improvement in oxygen levels compared to the control group, with a mortality rate of 9% versus 21% at day 28.
- Although the results were not statistically significant, findings suggest potential benefits of C5 inhibition for respiratory function and clinical outcomes, warranting further investigation in larger studies.
Article Synopsis
- This study investigated whether blocking the IL-6 or IL-1 pathways could help improve clinical outcomes in hospitalized COVID-19 patients suffering from hypoxic respiratory failure and cytokine release syndrome.
- A randomized, multicenter trial was conducted with 16 hospitals in Belgium, focusing on patients with specific criteria related to COVID-19 symptoms, oxygen levels, and markers of systemic inflammation.
- The trial employed a factorial design to assess the effectiveness of IL-1 blockade with anakinra compared to a control group, exploring its impact on the recovery timeline for severely ill patients.
Objectives: In patients with refractory or recurrent non-small-cell lung cancer (NSCLC) after first line chemotherapy, phase III trials showed superiority of nivolumab, an IgG4 programmed death-1 immune-checkpoint-inhibitor antibody, over docetaxel. We evaluated case mix, effectiveness and safety of nivolumab upon implementation in general practice.
Materials And Methods: In 20 general hospitals, all consecutive NSCLC patients treated with nivolumab within the medical need program (inclusion period 12 months) in Flanders - Belgium were evaluated.
Maxillary changes with bone-borne surgically assisted rapid palatal expansion: A prospective study.
Am J Orthod Dentofacial Orthop
March 2016
Introduction: The aim of this prospective study was to analyze the postexpansion positional changes of the maxillary halves and their initial stability after transpalatal distraction with a bone-borne distractor and standard corticotomies of the anterior, lateral, and median bony supports of the maxilla without pterygomaxillary disjunction.
Methods: The sample consisted of 21 patients (15 female, 6 male; mean age, 26 years 5 months). Measurements on the maxillary study casts and the posteroanterior cephalograms were obtained before surgery, at the end of palatal expansion, and 10 weeks later.
The objective of this study was to compare glass fibre reinforced (GFR) with multistranded bonded orthodontic retainers in terms of success rate and periodontal implications. A 2 year parallel study was conducted of 184 patients scheduled to receive bonded retainers in the upper and lower anterior segments. In three centres, the patients (mean age 14 years; 90 males and 94 females) were sequentially assigned to receive GFR retainers containing 500 unidirectional glass fibres (GFR500), 1000 unidirectional glass fibres (GFR1000), or multistranded retainers (gold standard).
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