Identification and Characterization of and subsp. Zinc Transporters.

Zinc uptake in bacteria is essential to maintain cellular homeostasis and survival. ZnuABC is an important zinc importer of numerous bacterial genera, which is expressed to restore zinc homeostasis when the cytosolic concentration decreases beyond a critical threshold. Upon zinc limitation the fast-growing nonpathogenic organism (MSMEG) as well as the ruminant pathogen subsp.

Complete Genome Sequence and Manual Reannotation of Mycobacterium avium subsp. Strain DSM 44135.

Here, we report the complete genome sequence of the subsp. reference strain DSM 44135, amended with a manual genome reannotation. The strain was originally described as strain 6783.

Critical Role of Zur and SmtB in Zinc Homeostasis of Mycobacterium smegmatis.

Zinc homeostasis is crucial for bacterial cells, since imbalances affect viability. However, in mycobacteria, knowledge of zinc metabolism is incomplete. (MSMEG) is an environmental, nonpathogenic that is widely used as a model organism to study mycobacterial metabolism and pathogenicity.

Link between Heterotrophic Carbon Fixation and Virulence in the Porcine Lung Pathogen Actinobacillus pleuropneumoniae.

is a capnophilic pathogen of the porcine respiratory tract lacking enzymes of the oxidative branch of the tricarboxylic acid (TCA) cycle. We previously claimed that instead uses the reductive branch in order to generate energy and metabolites. Here, we show that bicarbonate and oxaloacetate supported anaerobic growth of Isotope mass spectrometry revealed heterotrophic fixation of carbon from stable isotope-labeled bicarbonate by , which was confirmed by nano-scale secondary ion mass spectrometry at a single-cell level.