Publications by authors named "Elizaveta Igumnova"
Article Synopsis
- There is a critical need for new antimicrobial drugs due to rising bacterial resistance, prompting research into alternative compounds.
- Researchers synthesized a variety of sulfonamidobenzamide lead compounds inspired by marine antimicrobials, leading to the discovery of two effective compounds, G6 and J18, which show strong activity against MRSA and VRE.
- G6 also effectively disrupts bacterial biofilms and operates by targeting the cell membrane, similar to the biocide chlorhexidine.
Article Synopsis
- * The compound E23 was identified as highly effective, showing minimal inhibitory concentrations (MICs) of 0.5-2μg/ml against various Gram-positive bacteria, including MRSE and other resistant strains.
- * This research highlights the potential of marine-derived structural motifs to inspire the development of new antimicrobial agents.
Transfer and effects of 1,2,3,5,7-pentachloronaphthalene in an experimental food chain.
Comp Biochem Physiol C Toxicol Pharmacol
March 2015
Polychlorinated naphthalenes are environmentally relevant compounds that are measured in biota at concentrations in the μg/kg lipid range. Despite their widespread occurrence, literature data on the accumulation and effects of these compounds in aquatic ecosystems are sparsely available. The goal of this study was to gain insights into the biomagnification and effects of 1,2,3,5,7-pentachloronaphthalene (PeCN52) in an experimental food chain consisting of benthic worms and juvenile rainbow trout.
View Article and Find Full Text PDFObjectives: L-Arginine has been tested in various cardiovascular diseases, mainly to improve endothelial function through NO production. However, as the results have been partly unpredictable, we assessed the hemodynamic, energetic and metabolic effects of L-arginine to clarify any potential benefits in postischemic left ventricular (LV) dysfunction.
Methods: LV dysfunction was induced by repetitive brief coronary occlusions in 12 anesthetized, open chest pigs.