Publications by authors named "Elizaveta I Basanova"
Article Synopsis
- Growing scientific interest in orthopoxvirus infections spurred by the 2022 mpox outbreak has led to a focus on developing new antiviral compounds.
- This research focuses on synthesizing new 2-arylimidazoles that show effectiveness against several orthopoxviruses, including the variola virus.
- Among the various imidazole derivatives, 1-hydroxyimidazoles stand out for their strong antiviral activity and unique structural features, with the most promising compound showing high selectivity against vaccinia and variola viruses.
Background: In 1980, smallpox became the first viral disease eradicated through vaccination. After the termination of the Smallpox Eradication Program, the global immunization of the population also ceased. Now, most people do not have any immunity against infections caused by orthopoxviruses.
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