AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia in vivo.

The lack of regeneration in the human central nervous system (CNS) has major health implications. To address this, we previously used transgenic mouse models to show that neurogenesis can be stimulated in the adult mammalian retina by driving regeneration programs that other species activate following injury. Expression of specific proneural factors in adult Müller glia causes them to re-enter the cell cycle and give rise to new neurons following retinal injury.

Sterically Hindered Tellurium(IV) Catecholate as a Lewis Acid.

Sterically hindered tellurium catecholate Te(Cat) (Cat = 3,6-di--butyl-catecholate) was synthesized with the reaction of amorphous Te with 3,6-di--butyl--benzoquinone. Adducts of Te(Cat) with various O- and N-donors were isolated and characterized by means of single-crystal X-ray diffraction along with IR, UV-vis, and NMR (H, C, and Te) spectroscopies. In the crystal structure of the adduct with 2,2'-bipyridine (bipy), the unprecedented μ-κ,':κ,'-bridging coordination mode of bipy was observed.

Identification of a candidate genetic variant for the Himalayan color pattern in dogs.

Acromelanism is a temperature-dependent hypopigmentation pattern commonly manifested as the Himalayan coat color found in rabbits, rats, mice, minks, and gerbils, wherein the extreme "points" are dark and the torso is pale. It is known as the Siamese pattern in cats. Himalayan color is genetically determined by the allelic variant c of the locus C, later identified as the tyrosinase gene TYR.

Plasticizing of chitosan films with deep eutectic mixture of malonic acid and choline chloride.

Chitosan (CS) films containing deep eutectic solvent (DES) based on malonic acid (MA) and choline chloride (ChCl) were successfully prepared by solution casting method by using DES content ranging from 0 to 82 wt%. A strong interaction of CS with the components of DES was demonstrated by analyses of water sorption isotherms, atomic force microscopy and FTIR results. The plasticizing effect of the MA and ChCl mixture on the CS matrix was shown by static bulk mechanical measurements, thermal analysis and quantitative nanomechanical mapping (QNM).