Bioequivalence of Reference and Biosimilar Preparations of Premixed Biphasic Insulin Aspart: A Comparative Clamp Study.

Biphasic insulin aspart 30 is a premixed formulation containing a soluble fraction of insulin aspart (30%) and a protamine-crystallized fraction (70%) that was developed to combine the rapid-acting and prolonged advantages of commercially available insulins. The aim of this bioequivalence study was to compare the pharmacokinetics (PKs) of GP-bi-asp and Novo-bi-asp, and evaluate the pharmacodynamic (PD) properties as well as the safety of these drugs in the hyperinsulinemic euglycemic clamp (HEC) procedure. This was a phase 1, randomized, double-blind, 2-sequence, 2-period crossover study.

Processes in auroral oval and outer electron radiation belt.

We have analyzed the role of auroral processes in the formation of the outer radiation belt, considering that the main part of the auroral oval maps to the outer part of the ring current, instead of the plasma sheet as is commonly postulated. In this approach, the outer ring current is the region where transverse magnetospheric currents close inside the magnetosphere. Specifically, we analyzed the role of magnetospheric substorms in the appearance of relativistic electrons in the outer radiation belt.