[Study by radiolabelling of the residual time of a therapeutic gel in the nasal fossae].

The residence times in the nose of the liquid and gel forms of the same therapeutic preparation were compared in 7 healthy subjects. A 50 microliters drop of the preparation, labelled with Tc99m, was placed down the head of the inferior turbinate, and the kinetics of its clearance from the site of deposition was monotired using a gamma camera, during 60 minutes for the liquid and 120 minutes for the gel. The average times for removal of 50% of the labelled material from the site of deposition were 10.

Biointegration of massive bone allografts: imaging and histological studies in cat.

A study was carried out in a cat model to compare three imaging methods (X-ray, bone scintigraphy (BS) and magnetic resonance imaging (MRI] in order to assess the healing of bone allografts. X-ray remains the first technique to proceed, for morphological information and control of devices. BS is very sensitive although unspecific and difficult to quantify in exploration of bone reconstruction.

Anti-inflammatory activity of various superoxide dismutases on polyarthritis in the Lewis rat.

The anti-arthritic activity of four superoxide dismutases (SODs) has been compared by using the adjuvant-induced polyarthritis rat model. Many of the clinical signs observed in the rat closely resemble those of human rheumatic diseases and the Fiessinger-Leroy-Reiter syndrome. An original protocol and various approaches allowed study of the evolution of long term (30-90 days) SOD treatment.