Gpr75-deficient mice are protected from high-fat diet-induced obesity.

Objective: G-protein coupled receptor 75 (GPR75) has been identified as the high-affinity receptor of 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoactive and proinflammatory lipid, and mice overproducing 20-HETE have been shown to develop insulin resistance when fed a high-fat diet (HFD), which was prevented by a 20-HETE receptor blocker. Simultaneously, a large-scale exome sequencing of 640,000 subjects identified an association between loss-of-function GPR75 variants and protection against obesity.

Methods: Wild-type (WT) and Gpr75-deficient mice were placed on HFD for 14 weeks, and their obesity phenotype was examined.

Cultural Influences on Family Mealtime Routines in Mexico: Focus Group Study with Mexican Mothers.

Mexico's obesity rates are alarming, and experts project drastic increases in the next thirty years. There is growing interest in understanding how remote acculturation and globalization processes influence health behaviors. The present study used focus group data from a central state, San Luis Potosí, in Mexico to explore mothers' perspectives on factors that influence family mealtime routines.

Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics.

Polo-like kinase (PLK) family members play important roles in cell cycle regulation. The founding member PLK1 is oncogenic and preclinically validated as a cancer therapeutic target. Paradoxically, frequent loss of chromosome 5q11-35 which includes PLK2 is observed in basal-like breast cancer.

Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase.

Objective: 20-Hydroxyeicosatetraenoic acid (20-HETE) is a vasoactive eicosanoid exhibiting effects on vascular smooth muscle cell (VSMC) via G-protein coupled receptor 75 (GPR75) and include stimulation of contractility, migration, and growth. We examined whether VSMC-targeted overexpression of CYP4A12, the primary 20-HETE-producing enzyme in mice, is sufficient to promote hypertension.

Methods: Mice with VSM-specific Cyp4a12 overexpression (Myh11-4a12) and their littermate controls (WT) were generated by crossbreeding Cyp4a12-floxed with Myh11-Cre mice.

"It's Been Negative for Us Just All the Way Across the Board": Focus Group Study Exploring Parent Perceptions of Child Screen Time During the COVID-19 Pandemic.

Background: Child screen time (ST) has soared during the COVID-19 pandemic as lockdowns and restrictions have forced changes to regular family routines. It is important to investigate how families are navigating ST.

Objective: This study aimed to explore families' experiences of ST during the COVID-19 pandemic.

Rural Midwestern Mexican Fathers' Perspectives on Family Food, Mealtimes, and Physical Activity.

Two focus group interviews with eight low-income Mexican fathers in two communities in a rural Midwestern state explored fathers' perceptions, behaviors, and roles related to child and family food consumption, mealtimes, and physical activity. On average, fathers were 34 years of age, had 10 years of formal education, and annual household incomes ranged from $36,250 to $46,249. Findings include the identification of fifteen themes through the process of thematic analysis that are organized by five thematic areas of interest ().

Mealtime resistance: Hispanic mothers' perspectives on making healthy eating changes within the family.

Several perceived barriers to healthy eating within the family (e.g., cost, lack of time, energy, accessibility) are documented.

The Evolving Family Mealtime: Findings From Focus Group Interviews With Hispanic Mothers.

Background: Given the protective effects of shared family mealtimes and the importance of family in the Hispanic culture, this context should be explored further to determine how it can be leveraged and optimized for interventions.

Objective: This study aimed to explore contextual factors associated with family mealtimes in Mexican and Puerto Rican families.

Methods: A total of 63 mothers participated in 13 focus group interviews across 4 states.

Environmental Factors Influencing Physical Activity Among Latino Families: A Cross-country Comparison.

Objective: This study seeks to compare and contrast barriers to engage in physical activity (PA) among Latino parents in the USA and Mexico given different cultural and environmental contents.

Methods: Four bilingual and bicultural trained research assistants conducted focus groups in Mexico and the USA RESULTS: There were 33 total participants. Twenty-one mothers were married; most participants had not completed above a high school education.

Implementation and Evaluation of the Abriendo Caminos Program: A Randomized Control Trial Intervention for Hispanic Children and Families.

Objective: To describe the methodology of a family-focused, culturally tailored program, Abriendo Caminos, for the prevention of excess weight gain in children.

Design: Randomized control trial with outcome assessment at pretest, posttest, and 6 months after intervention or abbreviated-attention control group.

Setting: Community setting across 5 sites (Illinois, California, Iowa, Texas, and Puerto Rico).

Effects of Culturally Tailored Nutrition Education on Dietary Quality of Hispanic Mothers: A Randomized Control Trial.

Objective: To assess whether participation in a culturally tailored nutrition education program increases diet quality of Hispanic mothers.

Design: A randomized controlled trial.

Setting: Community centers and universities.

Sprouts Growing Healthy Habits: Curriculum Development and Pilot Study.

High rates of childhood obesity and the impact this has on children's health make it important to establish a healthy lifestyle during the early school years. This pilot study explored the impact of a newly developed healthy habits curriculum. The Sprouts: Growing Healthy Habits curriculum presents topics such as energy balance, healthy sleep habits, and food groups through short activities and interactive book-reading.

Correction to: The Effects of Hispanic Immigrant Mother's Resiliency on Children's Dietary Adjustment.

The original version of this article unfortunately contained errors in Affiliation 3, Acknowledgement, Table 1 and in the text under Methods section. Also, a Co-corresponding author has to be included in the article.

The Effects of Hispanic Immigrant Mother's Resiliency on Children's Dietary Adjustment.

This study explored the adjustment phase of the resiliency model of family adjustment and adaptation, particularly how stress and food insecurity interact with protective mechanisms to influence children's dietary adjustment. With increasing rates of Hispanic childhood obesity and disproportionate health disparities, this is an issue that must be better understood. Altogether, 137 Mexican immigrant mothers from Illinois and California completed questionnaires reporting their stressors, protective mechanisms, and family health behaviors.

Experiencing and Learning About Emotions: A Longitudinal Analysis of Youth Program Participants.

Organized youth programs provide a context where adolescents experience strong emotions and may develop new ways of thinking about and dealing with emotions. The current study examined youth's reports of positive and negative emotions arising during the course of their work in different types of project-based programs; learning about emotions from different sources (e.g.

Plk2 regulates mitotic spindle orientation and mammary gland development.

Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here, we demonstrate that Polo-like kinase 2 (Plk2) regulates mitotic spindle orientation in the mammary gland and that this might account for its suggested role as a tumor suppressor.

Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae.

Cooperation is central to many major transitions in evolution, including the emergence of eukaryotic cells, multicellularity and eusociality. Cooperation can be destroyed by the spread of cheater mutants that do not cooperate but gain the benefits of cooperation from others. However, cooperation can be preserved if cheaters are facultative, cheating others but cooperating among themselves.