The effects of alcohol preexposure on cocaine, alcohol and cocaine/alcohol place conditioning.

The present experiment examined the effects of alcohol preexposure on place conditioning with cocaine, alcohol or the cocaine/alcohol combination. Specifically, 91 male Sprague-Dawley rats were injected i.p.

The modulation of cocaine-induced conditioned place preferences by alcohol: effects of cocaine dose.

Busse and Riley [Biol. Psychiatry 26 (2002) 1373] have recently reported that alcohol dose dependently attenuated cocaine-induced place preferences. Although the mechanism for this effect is not known, it is possible that it is due to alcohol potentiating the aversive properties of cocaine, a potentiation that masks or abates cocaine's rewarding effects in this preparation.