Publications by authors named "Elizabeth T Dolan"
Article Synopsis
- Skeletal muscle mass and force production are regulated by complex systems, and activating dopamine 1 and 5 receptors in skeletal muscle may increase cAMP levels, potentially enhancing muscle mass and force.
- Experiments using the dopamine 1 and 5 receptor agonist SKF 81297 on isolated mouse muscles showed a rise in cAMP levels and reduced muscle mass loss due to disuse in wild-type mice.
- In contrast, dopamine 1 and 5 receptor knockout mice did not exhibit the same preservation of muscle mass and force during disuse, suggesting the importance of these receptors in maintaining muscle health.
Background: Muscle weakness is associated with a variety of chronic disorders such as emphysema (EMP) and congestive heart failure (CHF) as well as aging. Therapies to treat muscle weakness associated with chronic disease or aging are lacking. Corticotrophin releasing factor 2 receptor (CRF2R) agonists have been shown to maintain skeletal muscle mass and force production in a variety of acute conditions that lead to skeletal muscle wasting.
View Article and Find Full Text PDFBackground: Duchenne muscular dystrophy results from mutation of the dystrophin gene, causing skeletal and cardiac muscle loss of function. The mdx mouse model of Duchenne muscular dystrophy is widely utilized to evaluate the potential of therapeutic regimens to modulate the loss of skeletal muscle function associated with dystrophin mutation. Importantly, progressive loss of diaphragm function is the most consistent striated muscle effect observed in the mdx mouse model, which is the same as in patients suffering from Duchenne muscular dystrophy.
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