Publications by authors named "Elizabeth T Chimbayo"
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the persistence of cytokine producing T cells during memory cell maintenance and secondary responses. We interrogated antigen-specific CD4 T cells using a mouse influenza A virus infection model.
View Article and Find Full Text PDFTuberculosis (TB) remains a challenging global health concern and claims more than a million lives every year. We lack an effective vaccine and understanding of what constitutes protective immunity against TB to inform rational vaccine design. Moreover, treatment of TB requires prolonged use of multi-drug regimens and is complicated by problems of compliance and drug resistance.
View Article and Find Full Text PDFArticle Synopsis
- TZM-gfp is a new HIV-1 reporter cell line derived from JC.53, designed to express GFP under the control of HIV proteins Tat and Rev.
- The cells maintain high susceptibility to HIV infection, exhibit low background signal, and can detect HIV in rare infected cells amid a larger population.
- Their effectiveness is showcased through the ability to visualize single HIV-positive macrophages and to capture viral isolates from patient samples during co-culturing.