Bronchodilator response by interrupter technique to guide management of preschool wheeze.

Objective: We examined relationships between clinical features and pulmonary function before and after inhaled corticosteroid (ICS) treatment in wheezy preschool children, and specifically, whether measuring bronchodilator response (BDR) could predict benefit from ICS.

Design: Clinical non-randomised intervention study SETTING: Secondary care.

Patients: Preschool children (2 years to <6 years) with recurrent wheeze.

The effect of pre-industrial and predicted atmospheric CO concentrations on the development of diazotrophic and non-diazotrophic cyanobacterium: Dolichospermum circinale and Microcystis aeruginosa.

Photoautotrophs are capable of consuming high quantities of CO, yet scant research exists examining the influence of different CO concentrations on the growth of freshwater diazotrophic or non-diazotrophic cyanobacteria. In this study, we cultured two cyanobacteria taxa (Dolichospermum circinale and Microcystis aeruginosa) within controlled atmospheric CO chambers at pre-industrial, and post-industrial concentrations. Biovolume and chlorophyll a (Chl-a) differed as a consequence of the adjusted CO gradients.