A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation.

H2A.Z is an essential histone variant that has been implicated to have multiple chromosomal functions. To understand how H2A.

USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation.

H2A.Z, a variant of H2A, is found at the promoters of inducible genes in both yeast and higher eukaryotes. However, its role in transcriptional regulation is complex since it has been reported to function both as a repressor and activator.

Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin.

H2A.Z is a histone H2A variant that is essential for viability in organisms such as Tetrahymena thermophila, Drosophila melanogaster, and mice. In Saccharomyces cerevisiae, loss of H2A.

Detection of RNA in purified cytomegalovirus virions.

Five viral RNA transcripts have recently been detected in purified virions of human cytomegalovirus (HCMV) strain AD169, a well-characterized member of the family Herpesviridae [Science 288 (2000) 2373]. While the function of these transcripts and/or the proteins they encode remains to be elucidated, it is not known whether these transcripts are unique to strain AD169 or are present in other HCMV strains. The objective of this study was to determine if these RNAs are present in other HCMV laboratory strains (Towne and Davis), and a low passage clinical isolate (CL203).