Publications by authors named "Elizabeth Sandham"
Article Synopsis
- - ASPP2 plays a crucial role in maintaining the integrity of pseudostratified epithelia during development, particularly in the mouse E6.5 epiblast, where it prevents apical daughter cells from delaminating after cell division.
- - The protein helps organize the filamentous actin cytoskeleton at apical junctions, essential for tissue integrity during critical morphogenetic events like gastrulation and in various embryonic regions.
- - ASPP2's interaction with PP1 is vital for its tumor-suppressing function, highlighting its importance in tissues experiencing high mechanical stress, which could have implications for cancer research.
Declining ejaculate performance with male age is taxonomically widespread and has broad fitness consequences. Ejaculate success requires fully functional germline (sperm) and soma (seminal fluid) components. However, some aging theories predict that resources should be preferentially diverted to the germline at the expense of the soma, suggesting differential impacts of aging on sperm and seminal fluid and trade-offs between them or, more broadly, between reproduction and lifespan.
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