Quality of life during occlusion therapy for amblyopia from the perspective of the children and from that of their parents, as proxy.

Background: Parents pity their amblyopic child when they think that they suffer from occlusion therapy. We measured health-related quality of life during occlusion therapy.

Methods: We developed the Amblyopia Parents and Children Occlusion Questionnaire (APCOQ).

Differences in quality-of-life dimensions of Adult Strabismus Quality of Life and Amblyopia & Strabismus Questionnaires.

Purpose: The Adult Strabismus Quality of Life Questionnaire (AS-20) and the Amblyopia & Strabismus Questionnaire (A&SQ) both measure health-related quality of life in strabismus patients. We evaluated to what extent these instruments cover similar domains by identifying the underlying quality-of-life factors of the combined questionnaires.

Methods: Participants were adults from a historic cohort with available orthoptic childhood data documenting strabismus and/or amblyopia.

Patient-reported utilities in bilateral visual impairment from amblyopia and age-related macular degeneration.

Background: Utility of visual impairment caused by amblyopia is important for the cost-effectiveness of screening for amblyopia (lazy eye, prevalence 3-3.5 %). We previously measured decrease of utility in 35-year-old persons with unilateral persistent amblyopia.

Utility analysis of disability caused by amblyopia and/or strabismus in a population-based, historic cohort.

Background: Amblyopia (prevalence 3.4%) is in principle treatable, but approximately one quarter of children do not reach reading acuity in the amblyopic eye. Adults with persistent amblyopia and/or strabismus experience a decrease in quality of life.

Construct validation of the Amblyopia and Strabismus Questionnaire (A&SQ) by factor analysis.

Background: The Amblyopia and Strabismus Questionnaire (A&SQ) was previously developed to assess quality of life (QoL) in amblyopia and/or strabismus patients. Here, factor analysis with Varimax rotation was employed to confirm that the questions of the A&SQ correlated to dimensions of quality of life (QoL) in such patients.

Methods: Responses on the A&SQ from three groups were analyzed: healthy adults (controls) (n = 53), amblyopia and/or strabismus patients (n = 72), and a historic cohort of amblyopes born between 1962-1972 and occluded between 1968-1974 (n = 173).

Amblyopia and Strabismus Questionnaire (A&SQ): clinical validation in a historic cohort.

Background: We recently developed the Amblyopia & Strabismus Questionnaire (A&SQ) to assess the quality of life in amblyopia and/or strabismus patients, and evaluated its content and criterion validity. The A&SQ was now validated clinically by correlating its outcome with past and current orthoptic parameters in a historic cohort of amblyopia and/or strabismus patients.

Methods: The cohort was derived from all 471 patients who were treated by occlusion therapy in the Waterland Hospital in Purmerend between 1968 and 1974 and born between 1962 and 1972.

The Amblyopia and Strabismus Questionnaire: English translation, validation, and subscales.

Purpose: To establish the English-language version of the Amblyopia and Strabismus Questionnaire (ASQE).

Design: Prospective cohort study.

Methods: A structured translation process was followed to generate the ASQE, a 26-item instrument (originally in Dutch) containing five subscales for fear of losing the better eye, distance estimation, visual disorientation, double vision, and social contact and appearance.